Hartil-H

Hartil-H is a medicament that is used to treat and prevent diseases of the cardiovascular system. Let's consider the features of this medication, indications for use, dosage, methods of use, contraindications and possible side effects.

Hartil-N is available in the form of tablets at 2.5 and 12.5 mg. The drug has two active substances - ramipril 2.5 mg and hydrochlorothiazide 12.5 mg. In addition to active substances, the composition of the drug includes such components as: crospovidone, sodium stearyl fumarate, lactose monohydrate and others. Hartil-N is released on prescription, and when it is used, it is necessary to strictly observe the dosage and time of taking the medication.

Hartil-H is a highly effective drug that is used to treat and prevent cardiovascular diseases. The drug is valued for its effectiveness and ability to use with other medicines that are part of the treatment complex. The drug is released on prescription. Dosage and duration of use are also regulated by the attending physician.

[1], [2]

Indications Hartil-H

The main indications for the use of Hartil-H:

• Arterial hypertension
• Diseases and disorders of the heart
• Prevention of myocardial infarction
• Prevention for patients with hemodynamics
• The initial stages of diabetic and nondiabetic nephropathy
• Cardiovascular disorders
• Prevention and treatment of circulatory problems of the brain.

Hartil-H should be taken every morning, with plenty of fluids. The dose is assigned to each patient individually, being guided by the disease and the current symptomatology. Please note that the medication is not dependent on food intake. If the medication is prescribed to elderly people or patients with the presence of various chronic diseases, then the medical monitoring of the patient's condition is mandatory before use. Since very often, these patients have adverse reactions to Hartil-H.

[3]

Release form

The form of the release is a tablet. In each pack of medicine there are two blisters with 14 tablets each. That is, one package of Hartil-N is designed for a month of treatment. In some cases, patients are prescribed half a tablet, in this case they use Hartil-H packs for 14 tablets, that is, one blister.

Please note that the medication is available in cardboard packages, so it is almost impossible to verify the authenticity of the medication. To confirm the quality, you can require a certificate of compliance and a license. This is a guarantee that you will have a real Hartil-N in your hands.

[4]

Pharmacodynamics

Pharmacodynamics are the processes that occur with a medicine as soon as it enters the human body. The combination of the two active substances diuretic hydrochlorothiazide and ramipril exerts on the body a diuretic and antihypertensive effect. Three hours after taking, the medicine achieves the maximum effect, which can last for a week after the end of the admission.

The active components of the drug complement each other and quickly produce a therapeutic effect. Long-term use of Hartil-H leads to an exacerbation of chronic liver and kidney diseases. Therefore, taking the medicine should be strictly controlled.

[5], [6]

Pharmacokinetics

Pharmacokinetics are the processes of distribution, absorption and excretion of a drug. The maximum concentration of active components of Hartil-H is observed in the blood plasma one hour after administration, and the drug is absorbed in the gastrointestinal tract. Binding to blood proteins is at the level of 75%. A is metabolized in the liver, forms metabolites (active and inactive).

As for the excretion of Hartil-H, more than 60% is excreted in the form of metabolites with urine, and the remaining 40% with feces. The half-life is between 5 and 15 hours, the therapeutic effect is observed two hours after admission, and the maximum is within three hours. The action of active components of the drug, as a rule, lasts about 24 hours. But the optimal therapeutic result can be observed after 3-4 weeks of treatment with the help of Hartil-H.

[7], [8], [9]

Dosing and administration

The way of application and the dose of the medicine are prescribed by the doctor and completely depend on the symptoms of the disease and the state of the patient's body. But, regardless of this, the drug must be taken every morning, washed down with a copious amount of water. The use of the drug is not dependent on food intake. Let's consider the features of application and dosage.

• The dosage of each of the active components is selected individually for each patient. The initial dose of the drug is 2.5 mg of ramipril and 12.5 mg of hydrochlorothiazide. If a patient is prescribed a maintenance dose, the amount of the first drug is increased to 5 mg, and the second to 25 mg. In some cases, the dose of the drug may be 10 mg of ramipril and 50 mg of hydrochlorothiazide. But the safest dose is 5 mg of ramipril and 25 mg of hydrochlorothiazide.
• If the drug is prescribed to patients with kidney disease, the dose should be minimal, since the likelihood of side effects and symptoms of overdose is high. The maximum allowable dose is 5 mg of ramipril and 25 mg of hydrochlorothiazide.
• The drug is banned for use by patients who suffer from severe violations of the liver or cholestasis. Dosage of the drug should be minimal, and its use is monitored by the attending physician.

[15]

Use Hartil-H during pregnancy

The use of Hartil-H during pregnancy is not recommended. The first trimester is the most risky period for taking medication, since Hartil-H can lead to irreversible consequences. If the medication can not be stopped for medical reasons, it is recommended that you switch to the more secure Hartil-N analogues. Note that when planning pregnancy from a drug is also better to give up.

The medicine is not allowed in the 2nd and 3rd trimesters. Since this can lead to intoxication of the fetus, oppression of kidney function, delayed ossification of the bones of the skull and oligohydramnion. It is necessary to refuse taking medication during the period of breastfeeding, since the medicine can cause kidney failure, hyperkalemia or hypotension in the baby.

Contraindications

Contraindications to the use of Hartil-H depend on the individual characteristics of the organism and the reaction to the action of the active components of Hartil-H. So, the main contraindications to the application:

• Hypersensitivity to drug components
• The period of pregnancy and breastfeeding
• Impaired renal function, anuria
• Angionevrotic puffiness
• Cholestasis, impaired liver function.

Before appointing a patient a medicine, the doctor diagnoses the body for possible contraindications and side effects. In the case of contraindications, the patient is prescribed a smaller dose of medication or the analogues of Hartil-H are selected.

[10], [11]

Side effects Hartil-H

Side effects are manifested if the dosage of the drug, the admission regulations, or the patient has an individual intolerance to one of the active components of Hartil-H was not met. Let's look at the side effects of the drug:

• Syncope
• Arrhythmia
• Disorders of cerebral circulation
• Nausea and vomiting
•  Bronchitis and dry cough.
• Sleep and dizziness
• Allergic reactions to the skin
• Lakopenia and puffiness
• Impaired renal function and other symptoms.

If you experience any of the above side effects, you should stop taking the medicine and seek medical help.

[12], [13], [14]

Overdose

Overdosage of Hartil-N is possible with an incorrectly prescribed dosage or in the case when patients with the above contraindications begin taking the drug. Let's look at the main symptoms of an overdose of Hartil-H.

• Cardiac arrhythmia
• Convulsions
• Urinary retention and puffiness
• Intestinal obstruction
• Impaired consciousness and other symptoms.

In order to eliminate the symptoms of an overdose, the patient is rinsed with the stomach, and immediately after the symptoms of an overdose, sorbents (sodium sulfate or activated carbon) are given. When angioedema appears, the patient should immediately enter 0.5 ml of epinephrine or antihistamines.

[16], [17],

Interactions with other drugs

Interactions with other drugs are possible, but should be selected by the attending physician. Let's look at the frequent interactions of drugs and the possible side effects of their use

• The use of Hartil-H and indomethacin or acetylsalicylic acid may lead to a decrease in the hypotensive effect of the drug.
• With antihypertensive drugs and analgesics leads to antihypertensive effects of Hartil-H.
• The risk of leukopenia occurs when used with immunosuppressive drugs.
• Interaction with insulin and any other hypoglycemic agents increases the risk of hypoglycemia. Very often, this symptom is diagnosed in the first weeks of the combined use of Hartil-H and other drugs.

[18], [19], [20]

Storage conditions

The storage conditions must be in accordance with the prescriptions specified in the product instructions. Hartil-H, like other tablets is recommended to store in a dark, sheltered from sunlight and children's place. The temperature should not be below 25 ° C. It is recommended to keep the tablets in their original packaging.

If you do not comply with the storage conditions of Hartil-H, then this will cause the loss of its medicinal properties. In addition, due to non-compliance with the storage conditions of Hartil-H, the drug can change its color and acquire an unpleasant odor. In this case, the tablets should be disposed of, since their use can lead to uncontrolled reactions of the body.

[21], [22], [23], [24], [25], [26]

Shelf life

The shelf life of Hartil-H is indicated on the package of the drug and is 36 months. After the expiration date the drug is not allowed to be taken. The drug should not be taken if the conditions of its storage are not observed.

[27], [28]