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Gepadif
Last reviewed: 23.04.2024
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Indications Gepadifa
Used in combined treatment regimens for such disorders:
- acute or chronic hepatitis;
- alcoholic liver damage;
- hepatic cirrhosis ;
- poisoning associated with prolonged use of anticancer or antituberculosis drugs;
- hepatic dystrophy of fatty character;
- exogenous intoxication.
Release form
The release of the medicinal component is in the form of a lyophilisate for the preparation of an infusion fluid; 5 or 10 flakonchikov inside the package.
In addition, the drug is sold in gelatin capsules in the amount of 10, 30, 50 or 100 pieces inside a pack.
Pharmacodynamics
Hepadif is a complex medicine that acts due to the activity of its constituent elements. It stimulates biosynthetic and fat metabolism, prevents the development of hepatocyte necrosis, stabilizes the multiplication of hepatocytes and restores stable hepatic function and the production of specific enzymes.
Adenosine is a constituent of nucleic acids with coenzymes, as well as almost all cells located inside the body; It is an endogenous nucleoside that contributes to the regulation of hematopoietic processes. The component reduces the tone of the smooth muscles of the cell membranes inside the vascular bed and stabilizes the supply of oxygen to hepatocytes.
Vitamins from the B subcategory (such as pyridoxine with riboflavin and cyanocobalamin) are participants of the ERP and the binding of the most important amino acids (tryptophan with methionine, as well as cysteine, etc.), and in addition stabilize the metabolism of fats with proteins and carbohydrates. Together with this, vitamins help stimulate erythropoiesis.
The anti-toxic fraction, which contains essential, and in addition essential amino acids, provides antioxidant and detoxification activity to the medication.
Carnitine is involved in the breakdown of fatty acids, helps regulate fat metabolism and improves the absorption of food. The substance stimulates the production of bile, contributes to the digestion of food and facilitates the absorption of carbohydrates required to maintain a stable microflora inside the small intestine. At the same time, the drug increases cellular sensitivity to insulin and helps excrete it from the body.
Pharmacokinetics
After oral ingestion of capsules, the complex of active elements of the drug is released inside the duodenum. Affecting the entire length of the small intestine (mostly jejunum, as well as ileal), the absorption of carnitine with vitamins, as well as the anti-toxic fraction and adenine, is carried out.
Medicinal substances are distributed inside the intestines and kidneys with the liver. Highest riboflavin values are recorded inside the kidneys, myocardial cells, and livers. The exchange processes involving pyridoxine occur in the liver, and distribution is carried out inside the liver, muscle tissue and NS.
Excretion of metabolic products is mainly through the kidneys.
After intravenous injection of drugs through an IV, its elements are distributed inside the kidneys with the liver, brain, muscular tissues and cardiomyocytes. The metabolic processes are also carried out in the liver, and the excretion of metabolic products through the kidneys.
Dosing and administration
It is required to accept capsules orally, swallowing entirely and washing down with usual water. The duration of the treatment cycle and the dosing regimen are selected by the treating doctor.
An adult needs to take 2 capsules of drugs 2-3 times a day. A child over the age of 7 is prescribed 3 capsules per day, in 3 uses.
If you have problems swallowing the capsule, it is allowed to dissolve its contents in juice or plain water. It is forbidden to drink the capsule with milk or dissolve it in milk.
If the patient for any reason cannot use the capsules of Gepadif, he is prescribed the administration of the drug intravenously.
Use of intravenous drug injection.
Adults need to be administered per day at 8.625 mg / kg (usually this corresponds to the volume of the 1st bottle). It is necessary to introduce this portion once a day.
Before infusion, it is required to dissolve the powder in 5% glucose (0.5 l).
[8]
Use Gepadifa during pregnancy
Negative effects when used in pregnant or lactating women are not observed, but in the case of prescribing the drug to such patients, it is necessary to carefully assess the magnitude of the risk and benefit for the woman and child or fetus.
Contraindications
Main contraindications:
- erythrocytosis, erythema, as well as thromboembolism or nephrolithiasis;
- the presence of allergies to the elements of the drug;
- the presence of ulcers in the gastrointestinal tract (especially lesions in the acute phase).
Side effects Gepadifa
Often, Gepadif is tolerated without complications. But sometimes there may be some negative symptoms: nausea, obstipation, headaches, diarrhea, gastric indigestion, vomiting, and in addition, angioedema, urticaria, the acquisition of yellow shade with urine and rash.
[7]
Overdose
Intoxication with medication causes vomiting, polyneuropathy, diarrhea, and potentiation of the strength and frequency of negative symptoms.
To eliminate the disorders, they perform gastric lavage, inject activated carbon together with saline-type laxatives, and also perform symptomatic procedures.
Interactions with other drugs
Riboflavin is forbidden to combine with streptomycin, because this vitamin weakens the properties of antibacterial drugs (such as doxycycline with tetracycline, lincomycin and oxytetracycline).
The exchange processes of Gepadif, in particular, its effect on the heart, are weakened under the influence of amitriptyline, tricyclics and imipramine.
Pyridoxine reduces the effectiveness of levodopa and the incidence of negative signs of using isoniazid or other anti-tuberculosis drugs.
Impact on the degree of assimilation of cyanocobalamin have cimetidine, calcium, alcohol, and PAS.
Storage conditions
Gepadif is required to keep in a closed place from the penetration of children. Temperature readings - less than 25 ° C.
[11]
Shelf life
Hepadif may be used within a 5-year period from the date of manufacture of the pharmaceutical product.
Application for children
It is impossible to appoint in pediatrics (up to 7 years of age).
Analogs
Analogues of the medication are drugs Octamin Plus, Heptral, Tavamin, Carnitine with Carnitene, and in addition Heptor, Stimol, Alimba and Agwantar with Elkar. The list also includes Karnivit, Steatel, Le Karnit and Carnighel.
Reviews
Hepadif has a large therapeutic range, it is often used in combination with other drugs to maintain hepatic function. Reviews regarding its effectiveness are rather contradictory, because taking into account the type of the disease, the severity of the existing lesion, as well as joint treatment with other drugs, the drug can lead to the development of completely different effects. Negative manifestations develop rarely, mostly it is a violation of the chair or nausea.
Attention!
To simplify the perception of information, this instruction for use of the drug "Gepadif" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.