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Galidor
Last reviewed: 09.08.2022
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The drug Galidor (synonyms - Benzyclan, Benzyclane fumarate, Benzyclamide, Angiocycline) refers to the pharmacological group of myotropic antispasmodics, which, due to a decrease in the muscle tone of the tissues of internal organs and blood vessels, relieve spasms.
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Indications of the galidor
The drug Halidor is used in the complex treatment of blood vessel diseases associated with their narrowing (stenosis) or complete blockage (occlusion). These include obliterating atherosclerosis, obliterating endarteritis (thromboangiitis), peripheral forms of nonspecific aorto-arteritis. Galidor is also used in diseases of the vessels of the eyes (obstruction of the central artery of the retina, diabetic angiopathy, etc.)
The drug is prescribed for pathologies of cerebral vessels (acute and chronic forms of cerebral ischemia), with spasms of peripheral vessels characteristic of acrocinosis, idiopathic Reynaud's syndrome and fever.
Indications for the use of Galidor are diseases of the gastrointestinal tract and urinary system, which are accompanied by spasms of internal organs: gastroenteritis, peptic ulcer and duodenal ulcer, cholecystitis, cholelithiasis, colitis, spastic dissenosis of the large intestine, frequent painful urge to defecate ( tenesmus), flatulence after operations, spasms and tenesmus of the bladder.
Release form
The drug Halidor is available in two forms: in the form of tablets (100 mg each) and 2.5% solution (in 2 ml ampoules) for intravenous and intramuscular injections.
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Pharmacodynamics
The therapeutic effect of the preparation Halidor is based on the biochemical action of its active substance benzyclane (N, N-Dimethyl-3 - [[1- (phenylmethyl) cycloheptyl] oxy] -1-propanamine), which is capable of changing the ion balance in the membranes of smooth muscle cells.
As a result, activation of the cell enzyme ATP-pyrophosphate lyase with the simultaneous blockade of membrane proteins - adenosine receptors - is triggered. The result of all biochemical reactions is the reduction of cell contractions of the tissue of the visceral musculature (the muscles of the internal organs). Thanks to this there is a relaxation of muscles, a decrease in the tone of blood vessels and the removal of spasm.
Pharmacokinetics
Getting into the gastrointestinal cycle (when taking the drug inside), the active substance of the drug Galidor is rapidly absorbed, and its maximum concentration in blood plasma is reached on average after three hours. About 40% of the drug binds to plasma proteins, up to 30% for etritocytes, 10% for platelets.
After passing through the liver, the bioavailability of Halidor (after oral administration) is a maximum of 35%.
Benzyclone is metabolized in the liver; the final decomposition products are excreted in the urine (the half-life is between 6 and 10 hours). The speed of cleansing plasma from the drug substance (total clearance) is 40 liters per hour, the renal clearance is less than 1 liter per hour.
Dosing and administration
Halidor in the form of tablets in the pathology of the vessels is taken one tablet (100 mg) three times a day. The duration of treatment on average is two months, during which the doctor can reduce the dosage to one tablet twice a day.
To remove persistent spasms of internal organs, Halidor is prescribed 1-2 tablets (100-200 mg) - once a day; for maintenance therapy - on a tablet three times a day. The maximum daily dose of this drug is 400 mg, the duration of the course of therapy is no more than 1-2 months.
The method of application of Galidor in the form of 2.5% solution: intramuscularly (if necessary, intravenously - slowly) 1-2 ml per injection. In diseases of blood vessels, the solution can be infused (dropwise) into the vein (4 ml of the drug are diluted with 100-200 ml of isotonic NaCl solution).
When spasms of internal organs the drug is injected into a vein (with isotonic solution) or deep into the muscle. The standard course of treatment lasts no more than three weeks.
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Use of the galidor during pregnancy
The use of Halidor during pregnancy is contraindicated. If Galidor is prescribed, lactating women should stop breastfeeding while taking the drug.
Contraindications
Among the contraindications to the use of the drug Galidor are: severe forms of respiratory, renal, hepatic and decompensated heart failure, myocardial infarction, ventricular tachycardia, epilepsy, hemorrhagic stroke, craniocerebral trauma (suffered during the last year), age to 18 years.
Side effects of the galidor
When using the drug Halidor, the following side effects are possible: general malaise, dizziness, headache, dry mouth, nausea, vomiting, decreased (or increased) appetite, abdominal pain, diarrhea, tremor, sleep disturbances.
Memory disorders similar to epileptic seizures, cardiac rhythm disturbances, weight gain, and leukocyte reduction in blood (leukopenia) are also possible. Therefore, long-term use of the drug is necessary under the control of the blood composition.
Passing the course of treatment with Galidor, one should also consider the possibility of negative effects of this drug on the ability to drive a car and potentially dangerous mechanisms.
Overdose
Overdose of Galidor is expressed in the increase in heart rate, blood pressure decrease, spontaneous urination, drowsiness or anxiety; there may be a collapse, convulsive seizures. With such symptoms, a gastric lavage should be done.
Interactions with other drugs
Reception Galidor with drugs that reduce the content of potassium (diuretic, laxatives), enhances their effect. Admission with cardiac glycosides (digitalis preparations) can cause cardiac arrhythmias. The simultaneous use of Galidor with drugs for the treatment of cardiac arrhythmia or arterial hypertension (non-selective and selective beta-blockers) can cause tachycardia.
The interaction of Galidor with sedative (soothing) drugs and means for anesthesia is expressed in the intensification of their action on the central nervous system. And the use of Galidor and the intake of aspirin (acetylsalicylic acid) can disrupt aggregation (gluing) of platelets and lead to bleeding.
Storage conditions
This drug belongs to list B, it must be stored in a dry, protected from light and out of reach of children, the optimum storage temperature + 15-25 ° C.
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Shelf life
Galidor's shelf life in tablets is 5 years, solution for injections - no more than 3 years.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Galidor" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.