Gabantine 300

Gabantine 300 - one of the drugs that can effectively combat epilepsy, extending the periods of remission.

[1], [2], [3]

Indications Gabantine 300

Gabantine 300 is indicated for epilepsy, seizures in adults and children over 12 years of age, with neuropathic pain, migraine.

[4], [5], [6], [7], [8]

Release form

Gabantine 300 is available in capsules.

[9], [10]

Pharmacodynamics

The drug Gabantine 300 is an analogue of GABA. The final mechanism of action is still unclear. It is only structurally similar to GABA. Does not interact with sodium channels and binding sites.

[11], [12], [13]

Pharmacokinetics

The drug is rapidly absorbed. Its bioavailability is 60%. The maximum concentration of Gabantine 300 is reached after 3 hours. It is allocated by the kidneys in unchanged form after 5-7 hours. It is excreted during hemodialysis.

[14], [15], [16], [17]

Dosing and administration

Gabantine 300 is used regardless of food. Treatment begins with a dose of 300 mg, gradually increasing the daily dose to an effective dose of 900-1800 mg, dividing it into three doses.

Children aged 8-12 years. Treatment begins with a dose of 10-15 mg / kg / day. The effective dose is 25-30 mg / kg / day (in 3 divided doses).

[23], [24], [25], [26], [27]

Use Gabantine 300 during pregnancy

During pregnancy and breast-feeding can not be used - it penetrates through the placenta and into the milk.

Contraindications

Gabantin 300 is contraindicated in cases of sensitivity to gabapentin, during pregnancy, lactation and in children under 8 years of age.

[18], [19], [20]

Side effects Gabantine 300

On the part of the nervous system, drowsiness, ataxia, nystagmus, tremor, headache, depression, impaired consciousness, paresthesia and anxiety are possible.

From the digestive tract, indigestion, vomiting, eating disorders, constipation and pancreatitis occur.

On the part of the blood - leukopenia.

Tinnitus, urinary incontinence, rhinitis, rash, fever, purpura, swelling, discoloration of the tooth enamel, swelling of the blood sugar are also possible.

[21], [22]

Overdose

Gabantine 300 can be removed by hemodialysis. Diarrhea and speech disorders are possible.

[28], [29], [30]

Interactions with other drugs

The drug does not bind to plasma proteins, so the probability of interaction is low. Does not affect the effectiveness of preoral contraception. GABAPENTIN is taken no earlier than 2 hours after taking antacid preparations.

[31], [32], [33]

Storage conditions

Gabantine 300 can not be stored in the sun, above room temperature.

[34], [35], [36], [37], [38]