Furazolidone

Furazolidone is an antibacterial synthetic drug.

[1], [2], [3], [4], [5], [6], [7]

Indications Furazolidone

Indications for use

• Appearance of symptoms of dysentery, paratyphoid, giardiasis.
• The emergence of foodborne toxic infections.

[8], [9], [10], [11], [12], [13], [14], [15]

Release form

Medication is produced in tablets that have a yellow or yellow-green color, a flat-cylindrical shape and a bevel. Each tablet of abdominal pain is packaged in a contiguous, cellless package of ten pieces and placed in a cardboard pack of one or ten packs, supplied with a leaflet with instructions. Tablets can also be packaged in a contour cell package and placed in a cardboard box one, two, five, fifty or one hundred packs, accompanied by a storage instruction.

Each tablet contains fifty milligrams of active substance furozolidone, as well as a number of auxiliary substances lactose monohydrate, silicon dioxide colloidal anhydrous, calcium stearate, potato starch.

[16], [17], [18], [19], [20], [21], [22]

Pharmacodynamics

The drug shows an antimicrobial and antiprotozoanoe effect. Has a bacteriostatic effect against microorganisms. The action of furazolidone is based on a violation of the activity of the enzyme system of the bacterium.

Furazolidon affects staphylococci and streptococci, gram-positive bacteria-Escherichia coli, Shigella, Enterobacter, Proteus, Klebsiella, Salmonella, and also the simplest of the genus Lamblia. The action of the drug is highly sensitive to intestinal bacteria, which provoke dysentery, typhoid and paratyphoid. The development of resistance to the drug in these bacteria occurs at a slow pace.

[23], [24], [25], [26], [27], [28], [29], [30], [31]

Pharmacokinetics

Active substance Furazolidone is characterized by the quality of weak absorption in the blood and loses its effectiveness in the intestine. About five percent of the drug can be excreted from the body with the help of urine in a non-transformed form or in the form of metabolites. The urine of the patient becomes brown.

[32], [33], [34], [35], [36]

Dosing and administration

Furazolidon is taken orally, after eating, it is washed down with water. Adults use two to three tablets four times a day, with a course duration of treatment of five to ten days. A single maximum dosage is two hundred milligrams of the drug, and the daily dosage is eight hundred milligrams.

Children older than five take half the pill or tablet four times a day.

The course of treatment with the drug can not be longer than ten days.

[48], [49], [50], [51], [52], [53], [54]

Use Furazolidone during pregnancy

Medication is prohibited for use during pregnancy and breastfeeding.

Contraindications

• The presence of hypersensitivity to substances Furazolidon.
• The appearance of the terminal stage of kidney failure in the chronic form of the disease.
• Presence of deficiency of glucose-6-phosphate dehydrogenase.
• The patient's age is up to five years.
• Do not administer if an infection occurs that affects the urinary tract.

[37], [38], [39]

Side effects Furazolidone

Appearance of nausea, vomiting, loss of appetite.

The emergence of allergic reactions in the form of exanthema and enanthema.

Sometimes there is a reaction of hypersensitivity, which is characterized by reduced arterial pressure, the appearance of urticaria and arthralgia, an increase in body temperature. When the medicine is canceled, all of the above reactions go away.

In some cases, headaches may occur and symptoms of general malaise may occur, if the dose of furazolidone decreases, or the drug is withdrawn.

Some patients may develop a disulfiram-like reaction to alcohol intake, which is expressed in reddening of the skin, a slight increase in body temperature, the appearance of shortness of breath and a feeling of tightness in the chest.

To reduce the side effects, you need to drink the medicine with a lot of water or use a lower dosage. It is also necessary to use antihistamines, calcium chloride and B vitamins.

If side effects do not disappear, furazolidone should be discarded.

[40], [41], [42], [43], [44], [45], [46], [47]

Overdose

Appearance of symptoms of acute toxic hepatitis, hematotoxicity and neurotoxicity (polyneuritis).

If there are signs of overdose, it is necessary to cancel the drug intake, and also take a lot of fluids, B vitamins. Symptomatic treatment and taking antihistamines are also prescribed.

[55], [56], [57], [58]

Interactions with other drugs

Furazolidone is a drug that blocks the production of monoamine oxidase. Therefore, it should be used cautiously, as well as other medications from this group.

The action of aminoglycosides and tetracyclines leads to an increase in the antimicrobial effects of furazolidone.

There is increased sensitization of the body with alcohol.

The drug promotes oppression of hematopoiesis if taken together with Chloramphenicol and Ristomycin.

[59], [60], [61], [62], [63], [64], [65]

Storage conditions

Furazolidone - stored in a place that is protected from moisture and light, and from penetration of children at a temperature of up to 25 ° C.

[66]

Shelf life

Furazolidone is stored for 3 years from the date of manufacture.

[67], [68], [69], [70]