Fagotsef

Fagocef is a drug that is prescribed to patients with various infectious diseases. Let's look at the features of this drug, for what diseases it should be taken, how to take it correctly, and how effective it is. So, first things first.

Fagocef is an effective drug that treats many infectious diseases. But despite its effectiveness, the drug has many contraindications for use. Fagocef is administered intravenously, the drug is a powder for solutions. The drug is taken only as prescribed by the attending physician. As a rule, treatment with the drug is carried out only in a hospital setting.

Indications Fagotsef

Indications for use of Fagocef make it possible to find out for what diseases the drug is prescribed. So, Fagocef is used for infectious diseases caused by microorganisms sensitive to the drug.

The drug is prescribed for the treatment of the respiratory tract ( bronchitis, pneumonia, pleurisy ) and infectious diseases that affect these organs. Infectious lesions of the urinary tract ( urethritis, cystitis ) and kidneys ( pyelonephritis ). Also diseases of the skin, joints, soft tissues, bones ( osteomyelitis ). Prevention of complications of infectious diseases that may occur after surgical operations on the gastrointestinal tract, during obstetric and gynecological operations and urological operations. Diseases caused by infection in the central nervous system ( meningitis ), peritonitis and abdominal infections.

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Release form

The drug is available in injection powder form. The drug is available in 1000 mg vials. The drug is available in cardboard packages with 10 vials per package. When using the drug, dilute it with saline according to the dosage prescribed by the attending physician.

The main physical and chemical properties of the drug - the powder should be yellowish or white. When using the drug, special attention should be paid to the drug that will dilute the medicinal powder. Please note that the drug is strictly prohibited to use with such drugs as aminoglycoside, in the same dropper or syringe.

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Pharmacodynamics

Pharmacodynamics Fagocef distinguishes the drug as a semi-synthetic cephalosporin antibiotic for parenteral use. The drug has a bactericidal effect and a broad spectrum of action. The drug has an effect on infections such as:

• Streptococci - penicillinase-producing and penicillinase-non-producing strains.
• Bacillus subtilis and mycoides.
• Neisseria meningitidis.
• Proteus (indole-positive and indole-negative species).
• Salmonella.
• Haemophilus influenzae and parainfluenzae (penicillinase-producing and penicillinase-non-producing strains, including those resistant to ampicillin).
• Pseudomonas aeruginosa.

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Pharmacokinetics

Pharmacokinetics of Fagocef allows you to find out the features of the drug's behavior in the body. That is, the metabolism of the drug, its absorption and the period of excretion and distribution. After use, the drug is absorbed by the body within five minutes. Thus, with a single administration of an ampoule of the drug in 1000 mg, the concentration of the drug in the blood reaches 100 mcg / ml. The bactericidal concentration of the drug in the blood lasts for twelve hours.

70% of the drug is excreted in the urine. The remaining part of the drug leaves the body with bile and in the form of metabolites. On average, the half-life of the drug does not exceed one hour. If the drug is prescribed to elderly patients or patients with renal failure, the excretion time of the drug is doubled. The drug can also be prescribed to newborns, in which case the excretion time reaches 1.5 hours, and for newborn babies, this time reaches 6.5 hours.

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Dosing and administration

The method of administration and dosage of the drug are prescribed by a doctor and depend on the infectious disease being treated. Before starting treatment, it is necessary to check the body's reactions to the drug. Thus, all patients who are prescribed fagocef undergo a skin test for sensitivity to lidocaine. The drug is administered intravenously or intramuscularly. As a rule, for an average dose of the drug, 1000 mg of fagocef and 4 ml of sterile water for injection are dissolved. The drug is administered using a syringe or a dropper for 3-6 minutes.

• For children - for babies up to 7 days of life, the drug is administered at 50 mg / kg of body weight, every 12 hours. For newborns who are one month old, the drug is administered at 50 mg per kg of weight every 8 hours. For children from one year to 12 years weighing less than 50 kg, the drug is prescribed in a dose of 50 to 180 mg / kg. The exact dose depends on the disease. The drug is administered during the day, the number of injections can be from 4 to 6. The maximum dose of the drug should not exceed 12 g, that is, 200 mg per kg per day.
• For adults, the drug is taken every 12 hours, 102 g. The main condition for taking the drug is uncomplicated infectious diseases. If the patient has a moderate disease, the drug is used every 8 hours, and the dose is 1-2 g. In case of severe infectious diseases, phagocef is taken up to four times a day with a dose of 2 g. Please note that the maximum daily dose of the drug is 8 g.

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Use Fagotsef during pregnancy

The use of Fagocef during pregnancy is possible only for vital signs and as prescribed by a doctor. The safety of using the drug during pregnancy has not been established, that is, the use of the drug can lead to miscarriage or pathologies of the future baby. The drug is not recommended for use during lactation, since Fagocef is excreted in low concentrations through breast milk.

Fagocef is used to treat newborns and premature babies. That is, it can be used for babies intravenously, starting from the first days of life. Please note that when administered intramuscularly, the drug with a 1% lidocaine solution is strictly contraindicated for children under three years of age.

Contraindications

The main contraindications to the use of Fagocef are based on individual intolerance to the drug. Let's consider the main contraindications to the use of the drug.

• Hypersensitivity and individual intolerance to cephalosporin antibiotics.
• Individual intolerance to lidocaine.
• Breastfeeding and pregnancy.
• Kidney disease (prescribed with great caution, strictly monitoring the dosage of the drug).

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Side effects Fagotsef

Side effects of the drug Fagocef manifest themselves in the form of general reactions of the body, which have a negative impact on the body. The main side effects when using Fagocef:

• Digestive system - nausea, loss of appetite, diarrhea, vomiting, pseudomembranous colitis.
• Neuropenia, eosinophilia, hemolytic anemia.
• Cardiovascular system – arrhythmia (may occur with rapid administration of the drug).
• Urogenital system – renal dysfunction, interstitial nephritis, increased creatinine levels.
• Central nervous system - encephalopathy (occurs in patients with renal failure or when very high doses of the drug are administered).
• Anaphylactic reactions of the body – general weakness, anaphylactic shock, bronchospasms, angioedema.
• Skin reactions of the body – dermatitis, redness, rashes, urticaria, toxic skin necrosis, erythema multiforme, inflammation at the injection site.

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Overdose

An overdose of the drug causes a number of complications and rather unpleasant reactions of the body. The most common diagnosis that is made in case of an overdose of phagocef is reversible encephalopathy. There is no antidote that would protect the body from an overdose; in this case, symptomatic therapy is used. Hemodialysis or peritoneal dialysis are not effective in case of an overdose.

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Interactions with other drugs

Interactions of Fagocef with other drugs are possible during complex treatment. If the patient undergoes simultaneous treatment of diseases using potent diuretics, aminoglycosides or polymyxin, the risk of developing reversible renal failure increases.

When treating the body using phagocef and cefotaxime, aminoglycoside solutions cannot be used. The drugs must be administered separately. With the simultaneous administration of nifedipine and phagocef, the bioavailability of the drug increases by approximately 70%. Probenecid helps block the tubular secretion of phagocef and increases the half-life of the drug.

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Storage conditions

The storage conditions of Fagocef are fully consistent with the storage conditions of a number of other anti-infective drugs. The drug must be stored at a temperature of 15 to 30 degrees Celsius. The drug must be protected from direct sunlight and stored in a dark place.

Special attention when storing the drug is given to protection from children and sunlight. The drug solution can be stored for no longer than 24 hours, at a temperature of 2-8 degrees Celsius.

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Shelf life

Dates of production of phagocef. After the expiration date, the drug must be disposed of. It is strictly forbidden to use phagocef after the expiration date. Since an expired, spoiled drug will only aggravate the disease and cause a number of reversible reactions of the body (high temperature, fever, dizziness, nausea, vomiting, allergic reactions on the skin).

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