Ezopram

Antidepressant drug Ezopram refers to drugs - selective inhibitors of serotonin reuptake. The main ingredient of the drug is escitalopram, which is present in the form of escitalopram oxalate

[1], [2]

Indications Ezopram

Psychoanaleptic means Ezopram is prescribed for treatment and elimination of such painful conditions:

• significant episodes of depression;
• panic attacks accompanied (or not accompanied by) agoraphobia;
• social fears and anxiety disorders;
• general anxiety disorders;
• obsessive-compulsive disorder.

[3], [4], [5], [6], [7]

Release form

Esopram is produced in the form of tablets, covered with a filmy membrane. The tablet has a white color, an oval shape, the inscription "E" on one side and a notch for dosing.

Tablets are released in a dosage of 10 or 20 mg.

Packing of cardboard contains three blister plates, 10 pieces each. Tablets in each of them.

[8], [9], [10], [11], [12]

Pharmacodynamics

The active ingredient of the drug Ezopram refers to a series of selective serotonin reuptake inhibitors - s-isomers of racemic citalopram. The substance of escitalopram is almost a hundred times more effective than the r-enantiomer relative to the inhibition of serotonin capture. The drug significantly affects depressive and phobic states, while not reflecting on the re-uptake of noradrenaline, dopamine and γ-aminobutyric acid.

The products of the final metabolism of the drug Ezopram do not have antidopamin, antiadrenergic, antiserotonin, antiallergic and anticholinergic effects.

Long-term use of azopram does not affect a large number of receptors of chemical mediators of the central nervous system.

Ezopram does not have any effect on cardiac conduction or blood pressure, nor does it increase alcohol intoxication.

[13], [14], [15], [16], [17]

Pharmacokinetics

Ezopram is well absorbed in the digestive system, regardless of the presence of food masses in the stomach. Biological availability of the drug can reach about 80%. The limiting content of the active ingredient in the bloodstream is observed for 1-6 hours, with the stabilization of the therapeutic concentration 7-14 days after the start of treatment.

About 80% of the drug Ezopram forms a bond with plasma proteins, with an average volume of distribution of 12 to 26 liters per kilogram.

Removal of the drug in 30% is carried out by the kidneys, while the biological transformation occurs mostly in the liver. The main end products of metabolism are s-dimethyl citalopram and s-didymethyl citalopram, which have a weak pharmacological significance.

The duration of half-life is usually less than half an hour and may increase in elderly patients.

[18], [19], [20]

Dosing and administration

 Assign Ezopram for internal admission to patients of adult age, once a day, regardless of eating.

• For significant episodes of depression, take 10 mg of the drug daily. In rare cases, you can take the maximum allowable dosage of 20 mg. Efficacy becomes noticeable during 14-28 days from the beginning of therapy. After relief of the main signs of depression, the drug continues to be taken for another six months.
• At panic attacks in the initial 7 days take 5 mg of medication every day, then increase the dosage to 10 mg per day. At the discretion of the doctor, the amount of the drug can be brought up to 20 mg daily. Treatment should be continued for at least 3 months.
• At social infringements 10-20 mg of Ezopram in day can be appointed or nominated. Improvement is observed for 14-28 days from the start of therapy, but the drug continues to take at least 3 months.
• At the general disturbing frustration accept on 10 mg of a preparation daily, during 3 months. In some cases, an increase in dosage of up to 20 mg is possible.
• In obsessive-compulsive disorders, it is customary to prescribe 10 mg of the drug per day (sometimes up to 20 mg). Treatment, as a rule, long.

For elderly patients, it is recommended to lower the basic dosage to 5 mg daily. In extreme cases, it is allowed to increase it to 10 mg per day.

Do not abruptly cancel the treatment with the drug Ezopram. Dosage is lowered for 7-14 days, under the constant supervision of a doctor.

[28], [29], [30]

Use Ezopram during pregnancy

Reliable information on the use of azopram in therapeutic regimens during pregnancy and breastfeeding is extremely rare.

It is generally accepted that Esopram is contraindicated in such cases, unless the drug is vital.

Ezopram, which was used in later terms, can provoke the appearance of a newborn cyanosis, seizures, thermoregulation disorders and blood pressure, and other disorders. In addition, there is a possibility of developing a stable pulmonary hypertension in a child born.

Breastfeeding for the period of taking Ezopram is stopped.

Contraindications

Esopram is not prescribed in such situations:

• hypersensitivity reactions to this drug;
• with the simultaneous use of drugs-inhibitors MAO (there is a risk of developing serotonin syndrome);
• with the diagnosed elongated interval QT;
• in combination with Pimozide;
• at pregnancy, thoracal feeding, and also in children's age.

[21], [22], [23], [24], [25]

Side effects Ezopram

Side effects can be detected after 1 to 2 weeks from the start of therapy, and often go away alone with further administration of Ezopram:

• decrease in the number of platelets in the blood;
• allergy;
• disturbance of the production of antidiuretic hormone;
• change in appetite, change in body weight, anorexia;
• anxiety, heightened anxiety;
• deterioration of libido, lack of orgasm;
• overexcitation, neuroses, aggressive states, suicidal attempts, mania;
• pain in the head, sleep disturbances, numbness of the limbs, trembling in the fingers, change in taste;
• serotonin syndrome;
• deterioration of vision, dilated pupils;
• ringing in the ears;
• heart rhythm disturbances, QT interval elongation;
• a sharp drop in blood pressure;
• bleeding from the nose, frequent yawning;
• dyspepsia, thirst, internal bleeding;
• hepatitis;
• hyperhidrosis, rash on the skin, hemorrhages, peripheral edema;
• pain in the joints and muscles;
• difficulty with urination;
• menstrual cycle disorders;
• feeling tired.

There is also an increase in the risk of fractures: the exact causes of this phenomenon have not yet been established.

A sharp discontinuation of taking Esopram can lead to withdrawal syndrome, which is characterized by dizziness, sensory disturbances, dyspeptic phenomena, emotional instability.

[26], [27]

Interactions with other drugs

• Do not prescribe simultaneously Ezopram and drugs related to MAO inhibitors. In an extreme case, the time interval between taking these medicines should be at least 2 weeks.
• The combination of azopram and lithium preparations is undesirable.
• Individuals undergoing treatment with insulin or glucose should follow the insulin response with a possible correction of the amount of insulin.
• The combination of azopram and such drugs as Omez, esomeprazole, cimetidine requires caution: there may be side effects with the need to correct the amount of Ezopram taken.
• The combination of Ezopram with medicines based on St. John's Wort infestation usually leads to an increase in unwanted side-effects.

[31], [32], [33], [34], [35], [36]

Storage conditions

Esopram is stored in rooms with an air temperature of up to + 25 ° C, outside the reach of children.

[37], [38], [39], [40]

Shelf life

Ezopram is stored up to 3 years, in a sealed original package.

[41], [42], [43], [44]