Enat 400

Enat 400 is a simple vitamin supplement that contains the component tocopherol.

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Indications Enata 400

It is used in cases of hypo- or avitaminosis of type E. In addition, it is prescribed for combined antioxidant treatment, during the recovery period after injuries or severe somatic diseases, and also in connection with an unbalanced diet or physical overload.

As part of combination therapy it is used in the following situations:

• prevention of developmental disorders in the embryo or congenital defects in the fetus;
• in case of threat of miscarriage;
• climacteric disorders, menstrual cycle disorders and vulvar kraurosis;
• auditory impairments of a perceptual nature;
• atrophic lesions of the mucous membrane of the respiratory tract;
• affecting fibrous vertebral tissues, and along with this, large joints, changes of a proliferative and degenerative nature;
• muscle weakness associated with discogenic blockades in the case of diseases affecting the intervertebral disc, as well as SLE, scleroderma with rheumatoid arthritis and other general pathologies in the area of connective tissues;
• neurasthenia, accompanied by exhaustion (mainly muscular atrophy or dystrophy), muscle weakness of a secondary nature, as well as myopathy in the case of chronic arthritis;
• vegetative disorders;
• certain endocrine disorders and diseases affecting the cardiovascular system;
• atrophic lesions of the gastrointestinal mucosa, nutritional disorders, malabsorption syndrome, chronic hepatitis and alimentary anemia;
• individual periodondopathies;
• pathologies associated with the eyes;
• epidermal lesions: trophic forms of ulcers, dermatitis, eczema and psoriasis;
• Peyronie's disease, libido disorder, balanitis, dysfunction of the male sex glands, problems with potency and spermatogenesis, and in addition infertility (in combination with retinol).

Enat 400 can also be prescribed for hypervitaminosis subtypes A or D.

Release form

The release of the medicinal product is realized in capsules, in the amount of 10 pieces inside a cell plate. The pack contains 3 such plates.

Pharmacodynamics

Tocopherol is a fat-soluble vitamin that has a pronounced radioprotective and at the same time antioxidant effect, participates in the processes of heme and protein biosynthesis, cell proliferation and other important processes of cellular metabolism. The component improves oxygen saturation of tissues, has an angioprotective effect, affecting vascular permeability and tone by stimulating the processes of formation of new capillaries.

The immunomodulatory activity of tocopherol develops with stimulation of humoral and T-cell immunity.

This vitamin is essential for healthy reproductive function: conception, fetal development, and the formation and functioning of the reproductive system.

Tocopherol deficiency causes myocardial and skeletal muscle dystrophy, as well as hypotension, reduces the strength of capillaries and increases their fragility, and also leads to degeneration of photoreceptors, which causes visual impairment. Along with this, there is a weakening of reproductive activity in men, and in women - a disorder of the menstrual cycle, as well as an increased tendency to miscarriages.

A deficiency of tocopherol may result in hemolytic jaundice in newborns, as well as steatorrhea or malabsorption syndrome.

Pharmacokinetics

After intestinal absorption, the main part of the drug penetrates into the blood with lymph and undergoes rapid distribution within the body tissues, during which mainly accumulation occurs within the muscles, liver and fatty tissues. Maximum drug levels are noted within the pituitary gland with the myocardium, adrenal glands and sex glands.

The major part of Enata 400 is excreted in urine, and the remainder in bile.

Dosing and administration

Tocopherol is taken orally, after meals; the dosage portion is selected individually, taking into account the type of pathology and its course, as well as the patient's condition. The capsule is swallowed whole, while washing it down with plain water.

Portion sizes for different disorders:

• combined antioxidant treatment: 1-2 times a day, 200-400 mg;
• pathology in the development of the embryo or congenital anomalies in the fetus: 100-200 mg of the substance once a day, use in the 1st trimester;
• threat of miscarriage: administration of 100-200 mg of the drug per day, 14-day period;
• menstrual cycle disorders (combined course): 300-400 mg every other day; treatment should be started on the 17th day of the menstrual cycle (treatment should be repeated over 5 cycles);
• menstrual cycle disorders when using the drug before starting hormonal treatment: 100-200 mg of the drug 1-2 times a day for a period of 2-3 months;
• rheumatoid arthritis: 100-300 mg of the drug daily for a period of several weeks;
• muscular dystrophies or pathologies affecting tendons with joints and nerves with muscles: 100-200 mg 1-2 times a day for a 30-60-day period. A repeat treatment cycle can be carried out after 2-3 months;
• accompanied by exhaustion neurasthenia: 100 mg once a day for a period of 30-60 days;
• individual disorders of endocrine function: 300-500 mg of drugs per day;
• certain cardiovascular pathologies: 100 mg daily;
• anemia of alimentary origin: 300 mg of the substance per day, 10-day period of administration;
• chronic hepatitis: 300 mg per day for a long period;
• individual periodontopathies: 200-300 mg per day;
• eye diseases: 100-200 mg 1-2 times a day, over a 1-3 week period (combine with retinol);
• epidermal lesions: 100-200 mg 1-2 times per day, for a 20-40-day course;
• Peyronie's disease: 300-400 mg daily for several weeks, and later - as decided by the doctor;
• disorders of male potency with spermatogenesis: 100-300 mg of the drug per day, in combination with hormone therapy, over a 30-day cycle.

In other cases, the dosage size and duration of the course are selected by a medical specialist.

Adults need to take an average of 100 mg of the drug at a time. The maximum single dose is 400 mg. An average of 200 mg is used per day, and the maximum daily dose is 1000 mg.

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Use Enata 400 during pregnancy

During lactation or pregnancy, the medication can only be used under medical supervision and in recommended doses.

Part of the drug passes through the placenta, getting into the fetus's body. The amount of tocopherol in the fetus is 20-30% of the substance in the mother's blood plasma.

Tocopherol is also excreted in breast milk.

Contraindications

Main contraindications:

• severe sensitivity associated with the active ingredient and other substances of the drug;
• cardiosclerosis;
• myocardial infarction in the acute phase;
• hyperthyroidism;
• hypervitaminosis subtype E;
• intolerance to soy or peanuts.

Side effects Enata 400

Enat 400 is often tolerated without complications, but the use of high doses (0.4-0.8 g per day) can lead to potentiation of hypothrombinemia, and along with this to nausea with visual disturbances and stomach pain. Also to dizziness, and also to diarrhea, bleeding inside the gastrointestinal tract, enlargement of the liver, headaches, a feeling of general weakness or severe fatigue, digestive disorders or creatinuria.

Allergy symptoms may occur, including itching, rash, fever, and redness of the epidermis.

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Overdose

Administration of large doses of tocopherol (0.4-0.8 g per day over a long period of time) may cause diarrhea, visual disturbances, headaches, abdominal cramps or nausea, as well as dizziness, extreme weakness or fatigue. Increased CPK values, serum triglycerides and cholesterol levels may be observed, as well as increased androgen and estrogen values in the urine.

Extremely large doses (over 0.8 g, over a long period of time) may cause bleeding in people with vitamin K deficiency. It may also disrupt the metabolism of thyroid hormones and increase the risk of thromboembolism with thrombophlebitis in people with severe sensitivity.

To eliminate the disorder, tocopherol should be excreted from the body and then symptomatic measures should be taken.

Interactions with other drugs

Tocopherol is prohibited to be used in combination with silver or iron substances, as well as drugs with an alkaline environment (trisamine and sodium bicarbonate) and indirect anticoagulants (neodicoumarin with dicoumarin).

The drug potentiates the activity of SSAIDs and NSAIDs (ibuprofen with sodium diclofenac and prednisolone), and also reduces the toxicity of SG agents (digoxin with digitoxin), calciferol and retinol.

Tocopherol and its metabolic products have an antagonistic effect relative to vitamin K.

The drug increases the therapeutic effectiveness of anticonvulsants in people suffering from epilepsy.

Colestipol with cholestyramine and mineral oils reduce the absorption of tocopherol.

Using large amounts of tocopherol can lead to a decrease in the body's retinol stores.

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Storage conditions

Enat 400 should be stored in a place closed to small children. Temperature marks – in the range up to 25°С.

Shelf life

Enat 400 can be used within a 36-month period from the date of manufacture of the pharmaceutical product.

Application for children

The drug cannot be prescribed to pediatric patients (under 12 years of age).

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Analogues

Analogues of the substance are Vitrum, E-Zentiva, and Vitamin E.