Dazel

Let's consider the features of the drug Dazel, its pharmacology, interaction with other drugs and much more.

Indications Dazel

Indications for use of Dazel are vaginitis, which are treated with microorganisms sensitive to the drug. Dazel is an antiseptic, an antimicrobial drug that cures gynecological and venereal diseases. Let's consider the indications for use of Dazel and the drugs that are part of it.

Fluconazole is used for various types of fungal infections.

• For diseases of the central nervous system that are associated with yeast-like parasitic microorganisms.
• Treats cryptococcal meningitis, that is, inflammation of the brain caused by yeast-like parasitic microorganisms.
• Candidiasis of the mucous membranes, vaginal candidiasis.
• For diseases that can cause the development of fungal infections.

Azithromycin is prescribed for diseases caused by infectious agents.

• Infectious diseases of the upper respiratory tract.
• Inflammation of the paranasal sinuses, tonsillitis, otitis media.
• Infectious diseases of the lower respiratory tract (bacterial pneumonia, pneumonia ).
• Infectious lesions of soft tissues of the skin – erysipelas, dermatoses, skin diseases.
• Infectious diseases of the genitourinary tract - urethritis, inflammation of the cervix.

Secnidazole is prescribed as a synthetic antimicrobial bactericidal agent.

• Fights anaerobic bacteria and pathogens of protozoan infections.
• Promotes increased sensitivity of tumors to radiation.
• It works at the cellular level, promoting the destruction of the helical structure of DNA, breaking the strands, which promotes the death of infected cells.

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Release form

Dazel is a combination of antiseptic drugs that treat intimate problems in both women and men. So, the composition of Dazel includes:

• Fluconazole – 150 mg, uncoated tablets.
• Azithromycin – 1g, film-coated tablets.
• Secnidazole – 1g, film-coated tablets.

The drug is released in the form of tablets. One plastic Dazel contains three tablets. Let's take a closer look at the composition of Dazel drugs.

One tablet of the drug Dazel contains:

• Azithromycin - 1g, 1 tablet

The active substance of the tablet is azithromycin dihydrate, which is equivalent to anhydrous azithromycin. The excipients are corn starch, polyvinyl pyrrolidone, dibasic calcium phosphate, purified talc, and others.

• Fluconazole - 150 mg, 1 tablet

The active substance in the tablet is fluconazole. Excipients are sodium croscarmellose, microcrystalline cellulose, magnesium stearate and others.

• Secnidazole - 1g, 2 tablets

The active substance in the tablet is secnidazole. Excipients are magnesium stearate, colloidal silicon dioxide solution, microcrystalline cellulose and others.

Pharmacodynamics

Pharmacodynamics of Dazel is the localization of substances, their mechanisms of action, effects and various factors that are taken into account during treatment.

• Fluconazole is an antifungal drug that effectively acts against Candida albicans bacteria.
• Azithromycin is an antibiotic that has an antibacterial effect on Chlamydiatrachomatis and Neisseria gonorrhoea and belongs to the macrolide group.
• Secnidazole is an antiprotozoal agent that has an antimicrobial effect on infection. It effectively copes with microorganisms that cause bacterial vaginitis and Trichomonas vaginalis.

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Pharmacokinetics

Pharmacokinetics Dazel is responsible for the processes that occur with the drug in the human body. Let's consider how each of the drugs included in the Dazel drug complex work in the body.

• Secnidazole is completely but slowly absorbed in the body. As a rule, the effect of the drug is calculated for 17-30 hours. If the drug is taken by patients with giardiasis or amebiasis, the body's reaction occurs a day after taking the drug. In the case of hepatic amebiasis, treatment lasts for a week. The drug is well distributed throughout the body and does not concentrate in placental tissues. The time it takes for the drug to spread throughout the body is about 10 minutes. Due to slow absorption, the drug can remain in the intestine. But this is one of the advantages of the drug, since in the intestine it fights parasites such as amoeba and giardia.
• Fluconazole - oral administration of the drug is equal to intravenous administration in its effectiveness of distribution throughout the body. The highest concentration of the drug is observed in the blood plasma, 2 hours after taking the drug. But the half-life is about 30 hours. The drug is excreted in the urine, with about 80% of the drug leaving unchanged and 10% as metabolites.
• Azithromycin - the drug is well absorbed and spreads very quickly through the gastrointestinal tract. Such rapid action of the drug is associated with blood plasma proteins. The drug is excreted in the urine, while it leaves unchanged with bile.

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Dosing and administration

The method of administration and dosage of the drug Dazel are calculated for the entire complex of drugs in one platinum Dazel.

• Fluconazole is taken - 1 tablet before or after meals.
• Secnidazole is taken - 2 tablets during meals.
• Azithromycin is taken - 1 tablet 1-2 hours before meals.

The Dazel complex of drugs is intended for a single use of all drugs. If there is a need for a repeated course of treatment, the drug is prescribed by the attending physician.

Please note that while taking the drug, you must refrain from driving vehicles, drinking alcoholic beverages, and from work that requires high attention and quick psychomotor reactions.

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Use Dazel during pregnancy

The use of Dazel during pregnancy is prohibited, and the drug should not be taken during lactation, that is, breastfeeding.

The drug penetrates the placental barrier and can negatively affect the development of the baby. If the drug is taken in the early stages of pregnancy, it can provoke severe bleeding and miscarriage, and taking it in the last stages of pregnancy - premature birth and even asphyxia in the newborn.

Dasel is excreted in breast milk and enters the newborn's body. Therefore, during lactation, it is necessary to refuse taking the drug or stop breastfeeding.

Contraindications

Contraindications to the use of Dazel are associated with individual intolerance to the substances that are part of the drug. A number of contraindications include:

• Hypersensitivity to any antibiotic that belongs to the macrolide group.
• Age of patients – strictly prohibited for children and adolescents under 18 years of age.
• Hypersensitivity to any component of the drug, especially to fluconazole.
• The drug is contraindicated in organic diseases of the central nervous system.
• Hypersensitivity to substances in the drug that are nitroimidazole derivatives.
• The drug Dazel is contraindicated during pregnancy and lactation.
• Contraindicated in case of pathological changes in the blood, especially in the anamnesis.

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Side effects Dazel

Side effects of Dazel may be caused by the body's reaction to one of the components of the drug. Side effects include:

• Loss of motor coordination, ataxia, paresthesia, polyneuropathy.
• Dizziness and headache.
• Flatulence, unpleasant taste in the mouth.
• Diarrhea, abdominal pain.
• Vomiting and nausea.
• Neuropathy, leukopenia, thrombocytopenia.
• In patients with liver diseases, severe manifestations of hepatotoxicity, as well as cholestatic jaundice.
• Skin rashes, dermatitis.
• Anaphylactoid reactions.
• Toxic epidermal necrosis.
• Angioedema.

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Overdose

Overdose of the drug Dazel contributes to the enhancement of the above-described side effects and effects.

In case of overdose, seek medical help and stop taking the drug. Treatment is provided - symptomatic.

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Interactions with other drugs

The interaction of Dazel with other drugs depends on the substances that are included in the drug complex.

• Fluconazole - when interacting with anticoagulants, an increase in prothrombin time is observed. Simultaneous use by patients with diabetes mellitus with hypoglycemic agents is possible only after permission from the attending physician, since there is a high probability of hypoglycemia. When interacting with rifampicin, the period of fluconazole elimination is significantly reduced.
• Secnidazole - when interacting with anticoagulants, the latter's effect may be enhanced and even adverse reactions may occur. When used with disulfiram, there is a high probability of psychosis and paranoid reactions. Interaction of Dazel with non-depolarizing muscle relaxants is strictly prohibited. In case of simultaneous use of Dazel with a lithium preparation, a high concentration of secnidazole is observed in the blood plasma.
• Azithromycin - interaction with drugs ergot can cause ergotism. And when used simultaneously with cyclosporine, azithromycin increases the risk of toxic and adverse reactions of the drug, and azithromycin interferes with the metabolism of cyclosporine azithromycin.

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Storage conditions

Storage conditions for Dazel must fully comply with the recommendations specified in the instructions for the drug.

• The drug must be stored at a temperature of 15C – 30C.
• Protect the product from exposure to direct sunlight.
• Keep out of reach of children.

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Special instructions

Dazel is a universal medicinal complex that has a multifaceted antibacterial and anti-infective effect on the body. Before purchasing the drug, consult your doctor and get permission to use Dazel. The drug is available only on prescription.

Shelf life

The shelf life of the drug Dazel is three years from the date of manufacture, which is indicated on the package. After the expiration date, the drug must be disposed of and not taken.

Using an expired medicine can lead to irreversible consequences. Before taking the medicinal complex Dazel, be sure to pay attention to the expiration date.