Darsil

Darcil is a hepatoprotector that protects, promotes healing and restoration of the liver.

Indications Darsil

Darcil is prescribed for liver damage caused by toxic substances, as well as for inflammatory processes in the liver and cirrhosis as part of complex therapy.

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Release form

Darcil is available in tablet form.

Pharmacodynamics

The active component of Darcil is silymarin – a complex of flavonoids that fight free radicals in the liver, prevent cells from being destroyed, and restore hepatocyte membranes.

The drug promotes protein synthesis in damaged hepatocytes, cell regeneration, and prevents the loss of cellular elements.

In addition, Darcil inhibits the penetration of substances toxic to the liver (including death cap poison).

The drug improves the general well-being of patients, eliminates (or significantly reduces) the feeling of weakness, pain in the hypochondrium, and normalizes the functional state of the organ.

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Pharmacokinetics

Darsil has low absorption, binding to blood proteins practically does not occur. The drug undergoes biotransformation in the liver, participates in connecting reactions, in which sulfates and glucuronides are formed.

The drug is excreted from the body mainly by the gall bladder, and is absorbed into the systemic circulation in the small intestine. The half-life is about 6 hours. The drug practically does not accumulate in the body.

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Dosing and administration

The medication is taken after meals, the tablets should not be chewed or broken, it is recommended to wash them down with a small amount of water.

Adults are usually prescribed 1-2 tablets three times a day, children aged 5-12 are prescribed 3 mg of silymarin per 1 kg of weight (the dose should be divided into several doses). The duration of treatment is determined by the doctor, taking into account the severity of the disease, on average the medicine is taken for three months.

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Use Darsil during pregnancy

Darcil has not been tested in pregnant or breastfeeding women.

Contraindications

Darsil is contraindicated in cases of increased sensitivity of the body to the components of the drug, in case of exacerbation of chronic stomach diseases, acute poisoning, and the drug is not prescribed to children under 5 years of age.

Side effects Darsil

Darcil can cause headaches, indigestion, bloating, heartburn, nausea, and loose stools.

In some cases, shortness of breath, joint pain, decreased urine volume, skin rashes, and hair loss are observed during treatment with the drug.

All side effects disappear on their own after stopping the medication.

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Overdose

No cases of overdose were found during the Darcil study. In case of any overdose symptoms (nausea, vomiting, dizziness), symptomatic treatment is required (taking sorbents, gastric lavage).

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Interactions with other drugs

Darcil has the ability to enhance the therapeutic effect of antiallergenic, antifungal, hypocholesterolemic drugs, anticoagulants, antipsychotic drugs.

Darcil, when taken simultaneously, reduces the effectiveness of oral contraceptives and drugs used for hormone replacement therapy.

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Storage conditions

Darcil should be stored in a dry place, protected from sunlight, the storage temperature should not exceed 25°C.

Shelf life

Darsil is valid for 24 months from the date of manufacture; the medication is not used after the expiration date or if storage conditions are violated.