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Chorionic gonadotropin in the blood

Medical expert of the article

Obstetrician-gynecologist, reproductive specialist
, medical expert
Last reviewed: 05.07.2025

Elevated levels of human chorionic gonadotropin in the blood serum are detected as early as the 8th to 9th day after conception. During the first trimester of pregnancy, the concentration of human chorionic gonadotropin rapidly increases, doubling every 2-3 days. Subsequently, the increase in human chorionic gonadotropin levels slows down, reaching a maximum at 8-10 weeks of pregnancy, after which it begins to decrease and remains relatively constant during the second half of pregnancy.

In the second trimester of pregnancy, if the fetus has Down syndrome, the concentration of human chorionic gonadotropin in the pregnant woman's blood is increased, and AFP is decreased. Taking this into account, the study of AFP and human chorionic gonadotropin is used as a method of mass prenatal screening in the second trimester of pregnancy.

Serum Human Chorionic Gonadotropin Median Concentration Values for Screening Congenital Malformations in the Second and Third Trimesters

Gestational age, weeks

Medians for hCG, IU/l

14

63 900

14-15

58 200

15

43 600

15-16

38 090

16

37,000

16-17

35,000

17

34 600

17-18

34,000

18

33 400

18-19

29 100

19

26 800

19-20

23 600

20

20 400

20-21

20,000

21

19,500

In Down syndrome, the hCG level is elevated (2.0 MoM and higher), in Edwards syndrome, it is reduced (0.7 MoM). Complications in the third trimester of pregnancy most often occur with elevated levels of human chorionic gonadotropin.

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