Chloropyramine

Chloropyramin is an antispasmodic and antihistamine drug, which together with this and antiallergic, anticholinergic and hypnotic effect.

[1], [2], [3], [4]

Indications of the chloroepyramine

It is used to get rid of certain violations:

• inflammation of the eye conjunctiva, which is allergic in nature;
• an allergic intolerance that is seasonal in nature;
• angioedema;
• coryza of the vasomotor type;
• urticaria;
• an allergic reaction to the drug;
• a weak degree of bronchial asthma;
• skin lesions (eg, toxicodermia, neurodermatitis with eczema and contact or allergic dermatitis);
• serum sickness;
• itching, developing due to an insect bite;
• ARD (drying effect against mucous membranes).

[5], [6], [7]

Release form

The release of the substance is carried out in tablets having a volume of 25 mg. Inside each package contains 20 pieces.

[8], [9]

Pharmacodynamics

The drug reversibly combines with the endings of histamine (H1), while blocking their activity. This helps to eliminate the swelling in the nasal mucosa and the processes of hypersecretion, and in addition to spasms of bronchi, itching and spasms of smooth muscles. Together with this, the strength of the membrane of the vessels is strengthened and the capillaries are narrowed.

Has a hypnotic and antihistamine effect, as well as a strong antipruritic. The greatest effectiveness is shown when preventing allergies or reducing the intensity of already existing symptoms.

Due to the blocking of m-holinoretseptorov there is a moderate spasmolytic effect on smooth muscles - the muscle tone in the areas of the bronchi with the intestine and the bladder decreases.

[10], [11], [12], [13]

Pharmacokinetics

The medication is absorbed 100%, and its Cmax-index is marked inside the blood after 2 hours from the moment of drug use. He is held at this level in the period of 4-6 hours.

The distribution of the element occurs evenly. Exchange processes occur inside the liver, excretion of the medicament component - through feces and urine.

[14], [15], [16],

Dosing and administration

You should administer the medication orally, along with the food. The size of the adult dosage portion is 25-50 mg, with a 3-4-fold intake per day. For a day, a maximum of 150 mg is allowed. The sizes of children's portions depend on age and make 6,25-12,5 mg with 3-fold reception. For small children, it is allowed to rub the tablets into powder.

It is believed that the drug can be cautiously prescribed to children older than 1 month, but in such cases, the usefulness and dosage size should be determined by the doctor.

[27], [28], [29]

Use of the chloroepyramine during pregnancy

Pregnant is forbidden to be treated with Chloropyramine.

Contraindications

Among the existing contraindications:

• glaucoma, having a closed-angle shape;
• intolerance with regard to elements of drugs;
• astheno-depressive syndrome;
• lactation;
• BPH;
• the presence of pylorospasm;
• atonia affecting the function of the ureter or intestine;
• seizures of epilepsy;
• infants.

Caution is necessary for those people who suffer from delays in urination or ulcers inside the digestive tract, and in addition to those who take medications that suppress the central nervous system.

[17], [18], [19]

Side effects of the chloroepyramine

Taking pills can trigger the appearance of certain negative symptoms:

• problems with the coordination of various movements, a feeling of drowsiness, a slowing of the activity of psychomotor reflexes, dizziness, a significant deterioration in mindfulness;
• dryness affecting the nasal and oral mucosa and throat;
• diarrhea with severe nausea, a sharp decrease in appetite, or vice versa, its intensification, and in addition gastralgia;
• the emergence of tachycardia or arrhythmia, and at the same time a decrease in blood pressure.

[20], [21], [22], [23], [24], [25], [26]

Overdose

Poisoning in children is manifested by the following negative signs: a feeling of intense arousal or unexplained anxiety, the appearance of hallucinations or palpable convulsions, a moving pupil or its noticeable enlargement, the development of a collapse of the vascular type or hyperthermia, and at the same time involuntary movements performed by the feet and brushes.

Intoxication in an adult has the form of psychomotor-type excitation or a marked inhibition, as well as mental disorders. In addition, there may be convulsions or vascular collapse.

To remove the negative manifestations, you need to do a gastric lavage and appoint a patient to take anticonvulsants with sorbents, as well as caffeine. If appropriate indications are present, ventilation may be prescribed.

[30], [31], [32], [33], [34]

Interactions with other drugs

The drug potentiates the effect of sedative and hypnotic substances, narcotic analgesics, and at the same time anesthetics with atropine.

Tricyclics and tranquilizers can increase the inhibitory effect of chloropyramine on the CNS.

The drug does not have drug compatibility with ethyl alcohol.

[35], [36], [37], [38]

Storage conditions

The medication must be kept in a place where sunlight does not penetrate, with temperatures not exceeding 25 ° C.

Shelf life

The drug can be used within 24 months from the date of manufacture of the drug substance.

Reviews

Chloropyramine is an antihistaminic substance of the 1st generation, which has the ability for reversible synthesis with H1-termini, because of which, in order to obtain the desired therapeutic result, it must be consumed in large portions. Also, due to the fact that the effect of the drug is short-lived, the drug should be consumed 4 times a day, and in some situations even by 6 times.

Reception in large portions causes the development of a feeling of drowsiness and sedation, and in individual patients and dizziness. Because of these disorders, negative reviews about the therapeutic agent appear . This effect limits its use to patients whose work involves a quick reaction or good motor coordination. Therefore, the doctor must warn about the possible development of sedative effects before the appointment of a medication.