Chloropyramine

Chloropyramine is an antispasmodic and antihistamine drug, which also has antiallergic, anticholinergic and hypnotic effects.

[ 1 ], [ 2 ], [ 3 ], [ 4 ]

Indications Chloropyramine

It is used to get rid of certain disorders:

• inflammation of the conjunctiva of the eye of an allergic nature;
• seasonal allergic intolerance;
• angioedema;
• vasomotor rhinitis;
• urticaria;
• allergic reaction to medication;
• mild bronchial asthma;
• skin lesions (for example, toxicoderma, neurodermatitis with eczema and contact or allergic dermatitis);
• serum sickness;
• itching that develops due to an insect bite;
• ARI (drying effect on mucous membranes).

[ 5 ], [ 6 ], [ 7 ]

Release form

The substance is released in tablets with a volume of 25 mg. Each package contains 20 pieces.

[ 8 ], [ 9 ]

Pharmacodynamics

The drug reversibly combines with the endings of histamine (H1), along with this blocking their activity. This helps to eliminate swelling in the nasal mucosa and hypersecretion processes, as well as bronchial spasms, itching and smooth muscle spasms. Along with this, the strength of the vascular membrane is strengthened and the capillaries are narrowed.

It has a hypnotic and antihistamine effect, as well as a strong antipruritic effect. It shows the greatest effectiveness in preventing allergies or reducing the intensity of existing symptoms.

By blocking m-cholinergic receptors, a moderate spasmolytic effect on smooth muscles occurs - muscle tone in the areas of the bronchi with intestines and the bladder decreases.

[ 10 ], [ 11 ], [ 12 ], [ 13 ]

Pharmacokinetics

The drug is absorbed by 100%, and its Cmax indicator is noted in the blood after 2 hours from the moment of taking the drug. It is maintained at this level for 4-6 hours.

The element is distributed evenly. Metabolic processes occur inside the liver, and the medicinal component is excreted through feces and urine.

[ 14 ], [ 15 ], [ 16 ]

Dosing and administration

The medication should be administered orally, with food. The size of an adult dosage portion is 25-50 mg, taken 3-4 times a day. A maximum of 150 mg is allowed per day. The size of children's portions depends on age and is 6.25-12.5 mg taken 3 times a day. For small children, it is allowed to grind the tablets into powder.

It is believed that the drug can be carefully prescribed to children over 1 month old, but in such cases the appropriateness of use and dosage should be determined by a doctor.

[ 27 ], [ 28 ], [ 29 ]

Use Chloropyramine during pregnancy

Pregnant women are prohibited from taking Chloropyramine.

Contraindications

Among the existing contraindications:

• closed-angle glaucoma;
• intolerance to the components of the drug;
• asthenodepressive syndrome;
• lactation;
• prostate adenoma;
• presence of pylorospasm;
• atony affecting bladder or intestinal function;
• epileptic seizures;
• infants.

Caution is necessary for those people who suffer from urinary retention or ulcers inside the gastrointestinal tract, as well as those who take medications that suppress the central nervous system.

[ 17 ], [ 18 ], [ 19 ]

Side effects Chloropyramine

Taking pills can provoke the appearance of certain negative symptoms:

• problems with coordination of various movements, a feeling of drowsiness, slowing of psychomotor reflexes, dizziness, a significant deterioration in attentiveness;
• dryness affecting the nasal and oral mucous membranes and throat;
• diarrhea with severe nausea, a sharp decrease in appetite or, on the contrary, an increase in appetite, and in addition to this, gastralgia;
• the occurrence of tachycardia or arrhythmia, and along with this, a decrease in blood pressure.

[ 20 ], [ 21 ], [ 22 ], [ 23 ], [ 24 ], [ 25 ], [ 26 ]

Overdose

Poisoning in children is manifested by the following negative signs: a feeling of strong excitement or unexplained anxiety, the appearance of hallucinations or noticeable convulsions, a fixed pupil or its noticeable dilation, the development of vascular collapse or hyperthermia, and at the same time involuntary movements performed by the feet and hands.

Intoxication in adults takes the form of psychomotor agitation or noticeable inhibition, as well as disorders of consciousness. In addition, convulsions or vascular collapse may be observed.

To eliminate negative manifestations, it is necessary to perform gastric lavage and prescribe the patient to take anticonvulsants with sorbents, as well as caffeine. If there are appropriate indications, artificial ventilation may be prescribed.

[ 30 ], [ 31 ], [ 32 ], [ 33 ], [ 34 ]

Interactions with other drugs

The drug potentiates the effects of sedatives and hypnotics, narcotic analgesics, and also anesthetics with atropine.

Tricyclics and tranquilizers can increase the depressant effect of Chloropyramine on the central nervous system.

The drug is not medicinally compatible with ethyl alcohol.

[ 35 ], [ 36 ], [ 37 ], [ 38 ]

Storage conditions

The medicine must be kept in a place where it is not exposed to sunlight, at a temperature not exceeding 25°C.

Shelf life

The drug can be used within 24 months from the date of manufacture of the medicinal substance.

Reviews

Chloropyramine is a 1st generation antihistamine with the ability to reversibly synthesize with H1-endings, which is why it must be taken in large doses to achieve the desired therapeutic effect. Also, due to the fact that the effect of the drug is short-lived, the drug should be taken 4 times a day, and in some situations even 6 times.

Taking it in large doses causes drowsiness and a sedative effect, and in some patients, dizziness. These disorders are the reason for negative reviews of the therapeutic agent. This effect limits its use in patients whose work requires a quick reaction or good motor coordination. Therefore, the doctor must warn about the possible development of a sedative effect before prescribing the medication.