Cefodox

Cefodox is a semi-artificial antibiotic from the category of cephalosporins of the 3rd generation.

[1], [2], [3]

Indications Cefodox

It is used for therapy in pathologies of an infectious nature that develop due to the activity of microbes that are hypersensitive to the drug:

• sinusitis with laryngitis and tonsillitis, and in addition pharyngitis and otitis;
• pulmonary inflammation or bronchitis;
• pyelonephritis or cystitis (having moderate or mild severity);
• infections affecting the epidermis, bone and soft tissues, as well as joints;
• urethritis with proctitis, and in addition cervicitis of gonococcal etiology.

[4]

Release form

The drug is produced in tablets with a volume of 0.1 or 0.2 g. Inside the box - 10 tablets.

In addition, the drug is sold as a powder for oral suspension - in flakonchikah capacity of 50 or 100 ml.

[5], [6]

Pharmacodynamics

The bactericidal effect exerted by the drug on the body develops due to the ability to acetylate transpeptidase within the membranes of bacterial cells. As a result, there is a disruption in the formation of cell walls of microbes.

Many Gram-negative bacteria (such as Klebsiella, Providence, Escherichia coli, and in addition, myristibles, pseudomonads, serrations, hemophilic rods and cytrobacteria) possess a strong sensitivity to Cefodox, and in addition separate gram-positive microbes.

Low sensitivity is demonstrated by low-sensitivity anaerobes.

Many strains of enterococci with clostridia, mycoplasmas with legionella and chlamydia, and in addition stable staphylococcal strains relative to methicillin remain resistant to the drug.

[7], [8], [9], [10], [11]

Pharmacokinetics

The drug is actively absorbed inside the digestive system.

The bioavailability of the substance is about 52%. The medicinal component penetrates most of the tissues with secrets, cumulating inside them. Cumulation of cefpodoxim is noted inside the lungs with the liver, muscles, bone tissues and kidneys. In addition, it passes through capsules of abscesses into the cerebrospinal fluid. Metabolism is not affected by the substance.

Excretion of the drug is carried out with the help of kidneys.

[12], [13], [14], [15], [16]

Dosing and administration

Scheme of the use of tablets.

The antibiotic in tablets is allowed to be administered to adolescents over 12 years of age, as well as adults. The dosage amounts are 0.2-0.4 g.

For the treatment of diseases affecting the urogenital tract or the upper region of the respiratory system, and having an infectious origin, 0.2 g of medicament is prescribed per day. For therapy with pulmonary pneumonia or bronchitis, 0.4 g of substance are taken. Given the size of the portion, take the medicine 1-2 times a day.

The duration of the treatment cycle is determined by the nature of the course of the pathology and is selected by the physician.

Mode of application of the suspension.

To make the suspension, the following manipulations are carried out: first, you should shake the vial of powder, and then pour in it boiled cold water - to a special mark on the wall of the vial. The addition of water must be done in 2 steps; at the same time, the bottle must be shaken from time to time so that the mixture becomes homogeneous. You can use ready-made suspension after 5 minutes after manufacturing. Before each medication, you need to shake the container with the mixture.

Use a drug suspension is necessary with food. The interval between uses is 12 hours.

The daily portion of the medicine is 10 mg / kg. For a day, a maximum of 0.4 grams of medication is allowed. In this case, it should be taken in 2 doses, because the maximum permissible single dose is 0.2 g.

[20], [21], [22], [23], [24], [25]

Use Cefodox during pregnancy

Due to the fact that there have been no relevant tests on the effect of drugs on pregnant women, it is only possible to assign it to women at a given time if there are strict indications.

Because the active element of the drug cumulates inside the mother's milk, during the therapy it is required to refuse breastfeeding.

Contraindications

Contraindicated use in persons with hypersensitivity to the constituent elements of the drug.

Suspension can not be taken in people with galactosemia, malabsorption of glucose-galactose, and hypolactasia.

Side effects Cefodox

The use of medication can trigger the appearance of such side effects:

• the appearance of nausea, diarrhea, or vomiting;
• development of headaches;
• development of rashes or itching;
• increased plasma values of creatinine with urea;
• increased liver transaminase;
• disorder of leukocytopoiesis or thrombocytopoiesis;
• development of eosinophilia.

[17], [18], [19]

Overdose

Due to intoxication, the following symptoms may develop: diarrhea with nausea or vomiting. In persons with a deficiency of renal function, encephalopathy may appear, disappearing after a decrease in the plasma indices of the drug.

To eliminate the overdose, gastric lavage is required, as well as hemodialysis and symptomatic measures.

[26], [27], [28]

Interactions with other drugs

The use of antacids, as well as agents that block the activity of H2-endings, together with Cefodox, leads to a weakened absorption of the latter.

When combining a drug with nephrotoxic drugs, one should constantly monitor renal activity.

The combination of the drug with probenecid results in an increase in cefpodoxin values within the blood plasma.

[29], [30], [31], [32]

Storage conditions

Cefodox in tablets is kept out of the reach of children, at temperature elevations not exceeding 30 ° C. The ready-made suspension should be kept at a temperature within 4-6 ° C.

[33], [34], [35], [36]

Shelf life

Cefodox is allowed to be used within 24 months of the release of tablets. Shelf life of the finished drug suspension is a maximum of 2 weeks.

[37], [38], [39], [40]

Application for children

Tablets Cefodox is allowed to take only after reaching the 12th anniversary. Infants from 5 months are allowed to prescribe a therapeutic drug in the form of a suspension.

[41], [42], [43]

Analogues

Analogues of the drug are the drugs of Axef and Dockzef, and in addition Zinatsef, Cefpotec and Zocef.

[44], [45], [46], [47], [48], [49], [50], [51]

Reviews

Cefodox receives mostly positive reviews from adults and from parents who gave medicine to their children. For example, it quickly acts in infections that affect the upper region of the respiratory ducts - bronchitis and other infectious lesions. Patients note that the signs of the disease quickly pass away - pain, fever and so on. Plus, it is also considered that negative reactions to the drug develop only once.

Of the minuses, only the inconvenient form of release of the suspension is isolated.