Medical expert of the article
New publications
Preparations
Cebanex
Last reviewed: 09.08.2022
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Indications Cebanex
The main indications for the use of Cebanex are antimicrobial therapy. The drug is prescribed for patients with infectious diseases, which are caused by microflora, sensitive to the active substances of Cebanex. The drug is prescribed for:
- Infectious lesions of the respiratory system and respiratory tract ( sinusitis, bronchitis ).
- Infections of the pelvis and abdominal organs ( peritonitis, cholangitis, cholecystitis ).
- Infectious diseases of the joints (bursitis), bones ( osteomyelitis ), soft tissues ( furuncles ), as well as meningitis and septicemia.
In particularly difficult cases, Cebanex is prescribed as part of a comprehensive antimicrobial therapy. The drug perfectly interacts with a number of antibiotics that have a bactericidal effect.
Release form
The form of the preparation Cebanex is a powder for the preparation of injections. The drug is produced in glass bottles for parenteral use at 1 and 2 g. Each carton contains one bottle of Zebanex.
This form of release facilitates the process of using the drug. Using a syringe, inject the solution into the vial and shake it thoroughly until Cebanex is completely dissolved.
Pharmacodynamics
Tsebanex is a complex preparation of a wide spectrum of action. The main active substances of this antimicrobial agent are sulbactam and cefoperazone.
- Sulbatkam is an inhibitor of beta-lactamase, which has virtually no antimicrobial effect. But the work of this substance is that the sulbatkam enhances the action of cefoperazone.
- Cefoperazone is an antibacterial agent of the third generation of cephalosporins. It actively destroys bacterial microorganisms, which are at the stage of division and multiplication.
The drug Cebanex has an active effect on infections caused by gram-negative and positive aerobic bacteria, the drug has an effect on cocci and bacilli. Before prescribing the drug, it is very important to test the sensitivity of the strains of Acinetobacter calcoaceticus, Neisseria gonorrhoeae. But the drug does not have the proper effect on staphylococci and mycoplasma. The active substances Cebanex quickly and effectively penetrate into biological fluids and tissues, overcoming the hematoplacental barrier.
Pharmacodynamics Zebaneks - these are the processes and actions that the drug has on the body and bacteria. The drug refers to cephalosporin antibiotics, therefore it affects sensitive microorganisms that are in the stage of reproduction. The drug works by inhibiting the biosynthesis of the mucopeptide of cell membranes.
The combination of active substances Cebanex shows activity to all microorganisms that are sensitive to cefoperazone. The drug is active against gram-negative aerobic bacteria, cocci, bacilli and gram-negative cocci and bacilli. It is also active against resistant mycoplasmas and methicillin-resistant staphylococci.
Pharmacokinetics
The pharmacokinetics of Cebanex are the processes of metabolism, absorption, distribution and excretion of the drug. Let's consider all these processes occurring with the drug after ingestion.
- Absorption - the drug is concentrated in blood plasma after 30 minutes with 1 g of cefoperazone and 15 minutes after using 0.5 g of the drug.
- Distribution - in adult patients, the distribution begins five minutes after the dose is given in 2g. The distribution rate is 10-12 liters. In this case, the binding to blood proteins at 80%. The drug perfectly penetrates into the body fluids and tissues. Please note that during the distribution of the active substances of the drug penetrate through the placental barrier, so its use during pregnancy is not desirable.
- Excretion and metabolism - the half-life of the drug is 1-2 hours. Part of the drug is metabolized in the kidneys and liver. Tsebanecs is excreted in urine, bile and feces.
Dosing and administration
The route of administration and dose of Cebanex are regulated and appointed by the attending physician. Thus, the drug is intended for intravenous, intramuscular or drip administration. As a rule, before using the drug, the patient is given a skin test for allergic reactions to the active substances of the drug. To prepare the injection, the doctor dilutes the contents of the Zebanex vial to a concentration of 100 mg per ml. For dilution, use water for injection, dextrose solution or sodium chloride solution.
As for the dosage of the drug, it depends on the disease that is treated and the individual characteristics of the patient's body. Severe infectious diseases - 0.5-1 g of cefoperazone twice a day. Uncomplicated urethritis - a single injection of 0.5 g of cefoperazone. In all other cases, the dose of the drug is regulated by a doctor, but does not exceed 4 g of active substance Cebanex per day.
Use Cebanex during pregnancy
The use of Cebanex during pregnancy is possible only if the potential benefit for maternal health is much more important than the normal development of the fetus. During pregnancy, the drug can also be prescribed for medical reasons. But, as a rule, Cebanex is replaced with safer drugs.
If the drug is prescribed during lactation, it is necessary to consult a doctor. The doctor should prescribe analogues of the drug that do not enter the mother's milk and into the baby's organism or prohibit breastfeeding. Some women have to interrupt the period of lactation due to taking Cebanex.
Contraindications
Contraindications to the use of Cebanex, however, as well as contraindications to any other drug, are primarily based on individual intolerance of the active components. The drug is not recommended for people with intolerance to cephalosporin and penicillin antibiotics. Particular attention when taking the drug should be given to patients who are prone to allergic reactions.
Cebanex is administered with caution to patients with a weak immune system, people who adhere to limited diets or are on parenteral nutrition. For patients with diseases of the kidneys, liver, gall bladder and advanced age, a minimum dose of the drug is prescribed. But the reception of Cebanex by pregnant women is possible only under medical supervision, especially in the first and last trimesters.
Side effects Cebanex
Side effects of Cebanex completely depend on the characteristics of the patient's body and the used dose of the drug. So, the lower the dosage, the less dangerous and damaging the side effects. Let's look at the common side effects of Cebanex:
- Headache, dizziness
- Leukopenia
- Reduction of blood pressure
- Pseudomembranous colitis (with prolonged therapy)
- Decreased hemoglobin level
- Nausea and vomiting
- Stool disorders, metiorism
- Allergic reactions to the skin
- Phlebitis at the site of injection and other symptoms.
If side effects of the drug occur, it is necessary to stop taking it and seek medical help.
Overdose
Overdose Cebanex is possible if the dosage of the drug is not complied with or the rules of use. So, the introduction of high doses is the cause of the appearance of adverse reactions. The main symptoms of an overdose are manifested by the nervous system. Cramps may appear in patients because of an increased concentration of cebanex active substances in the cerebrospinal fluid.
Antidote for overdose treatment does not exist. To remove the symptoms of overdose use of medical therapy. In the case of severe intoxication drug patients with chronic diseases or impaired renal function, dialysis is performed.
Interactions with other drugs
The interaction of Cebanex with other drugs is possible only with the permission and appointment of a doctor.
- Tsebanes can not be mixed in one syringe with other medications and aminoglycosides.
- The drug can be mixed with compatible infusion solutions, which are used as solvents.
- If, in addition to Tsebaneks, the patient is prescribed injections of aminoglycosides, then the drugs must be injected into different parts of the body, adhering to the interval of an hour and a half.
- Zebanex does not interact well with drugs that have bacteriostatic effects, as they reduce the effectiveness of Cebanex.
- When interacting with probenecid, the half-life of Cebanex increases.
- When using the drug is strictly prohibited to take medicines, which include ethyl alcohol, as well as any alcoholic beverages.
Storage conditions
The storage conditions of Cebanex must comply with the instructions of the preparation. Vials with the drug can be stored no longer than two years from the production date, which is indicated on the package. Zebanex should be stored in dry rooms, at an air temperature not exceeding 25 degrees.
The ready-made Cebanex solution can be stored for no more than 24 hours, observing a temperature regime of 15-25 degrees and no longer than 48 hours at a temperature of 5-10 degrees. If the integrity of the package of the preparation has been violated during the storage process, it is not recommended to take Cebanex.
[10]
Shelf life
Shelf life is indicated on the packaging and is 24 months. After the expiration date, the drug must be disposed of, since it is forbidden to take it. Please note that if the storage conditions are not respected, the drug loses its medicinal properties, and hence its shelf life.
[11]
Attention!
To simplify the perception of information, this instruction for use of the drug "Cebanex" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.