Causes of magnesium increase and decrease in blood

Hypomagnesemia occurs due to the following reasons.

• Reduced absorption of magnesium in the intestines due to malnutrition, impaired absorption, prolonged diarrhea. This is the mechanism of development of hypomagnesemia in acute and chronic dyspepsia, enterocolitis, ulcerative colitis, acute intestinal obstruction, edematous pancreatitis, alcoholism.
• Increased magnesium excretion by kidneys due to hypercalcemia, osmotic diuresis or the taking of such drugs as loop diuretics, aminoglycosides, cyclosporine. Any damage to the renal tubules leads to an increase in the excretion of magnesium in the urine. Approximately 30% of patients with diabetes mellitus develop hypomagnesemia, but with severe forms of the disease it is difficult to detect due to a decrease in the volume of intravascular fluid. Against the background of hypomagnesemia, diabetes mellitus is more severe. The ratio of Mg / creatinine in urine in patients with diabetes mellitus increases in proportion to the severity of the clinical course of the disease.

In clinical practice, magnesium deficiency occurs more often than it is diagnosed (approximately in 10% of inpatients).

Magnesium - one of the regulators of vascular tone, promotes dilatation of the vascular wall. A low concentration of extracellular magnesium leads to vasospasm or increases their sensitivity to pressor agents. The intracellular magnesium content correlates with the value of arterial pressure in patients with arterial hypertension. The effect of a number of drugs that lower blood pressure, is realized through magnesium. A decrease in the magnesium content in the myocardium was observed in patients who died from myocardial infarction and in blood in patients with ischemic heart disease. A sharp fall in the concentration of magnesium in the blood can be one of the causes of sudden death.

Magnesium refers to hypolipidemic agents. Hypomagnesemia contributes to the activation of the atherosclerotic process. Hyperlipidemia against hypomagnesemia promotes the progression of fatty liver infiltration. In hypomagnesemia, the activity of heparin-dependent lipoprotein lipase and lecithin cholesterol acyltransferase decreases. A violation of the clearance of LDL in a lack of magnesium explains the development of hyperlipidemia in diabetes mellitus.

With magnesium deficiency, platelet aggregation increases, thrombus formation processes are activated, so magnesium is considered a natural anticoagulant.

Hypomagnesemia is a frequent complication of alcoholism and alcohol abstinence. Hypomagnesemia also accompanies hypophosphatemia (severe hyperparathyroidism and thyrotoxicosis) and intoxication with cardiac glycosides.

When evaluating the results of a study of magnesium in the blood serum, one should always remember the "false" hypomagnesemia, which can be under stress, acute infectious diseases, hypovolemia.

Hypomagnesemia often causes hypokalemia and hypocalcemia, which is reflected in the clinical picture. Neurological disorders include drowsiness, confusion, tremor, involuntary muscle contraction, ataxia, nystagmus, tetany, and convulsive seizures. On the ECG, the intervals PQ and QT are lengthened. Sometimes there are atrial and ventricular arrhythmias, especially in patients receiving digoxin.

Sometimes severe cardiac arrhythmias can be corrected by magnesium preparations (with their intravenous administration), even in cases when traditional antiarrhythmic therapy is ineffective.

It should be emphasized that the magnesium deficiency (as well as its excess) in the body is difficult to detect, which is due to its low correlation with the concentration of magnesium in the blood serum.

Hypermagnesia occurs with renal insufficiency, the use of lithium drugs, hypothyroidism, lactic acidosis, hepatitis, neoplasms, the use of magnesium preparations against the background of undiagnosed renal failure. Clinical manifestations usually develop at a magnesium concentration in the serum of more than 4 meq / l. Neuromuscular disorders include areflexia, drowsiness, weakness, paralysis and respiratory failure. Cardiovascular disorders include arterial hypotension, bradycardia, prolongation of PQ, QRS and QT intervals on the ECG, complete atrioventricular block and asystole. The association of clinical disorders with the concentration of magnesium in the serum is as follows:

• 5-10 meq / l - the delay in conducting pulses through the conduction system of the heart;
• 10-13 meq / l - loss of deep tendon reflexes;
• 15 meq / L - respiratory paralysis;
• more than 25 meq / l - cardiac arrest in the diastole phase.

[1], [2], [3], [4], [5], [6], [7], [8], [9]