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Causes of copper deficiency in the blood

Alexey Portnov, medical expert
Last reviewed: 23.04.2024

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Inadequate intake of copper in the body of children underlies 3 clinical syndromes.

Anemia (in infants, when they are fed mostly with dry or fresh cow's milk), anorexia and a low copper content in the blood.
Neutropenia, chronic or intermittent diarrhea, decreased copper concentration and ceruloplasmin activity in the blood, impaired calcification of bones, anemia (due to a violation of iron ferritin use).
Syndrome Menkes (the result of a genetically determined defect in copper absorption).

Metabolic disorders with copper deficiency

Pathology	Metabolic Defect	Insufficient enzyme
Achromotrihia	Disturbance of melanin synthesis	Tyrosinase
Violations of the formation of the cardiovascular system, skeleton, collagen and elastin	Violation of the formation of "stitching" of collagen and elastic fibers	Amino oxidase of connective tissue (lysyloxidase)
CNS lesion	Myelin hypoplasia	Cytochrome-C-oxidase
CNS lesion	Violation of the synthesis of catecholamines	Dopamine-.beta.-hydroxylase

The most important diseases, syndromes, signs of deficiency and excess of copper

Deficiency of copper in the body

Excess of copper in the body

Hereditary forms of hypo- and sporopreosis: Menkes disease (illness of "curly hair" with severe CNS damage); Marfan syndrome (skeletal anomalies, elastic and collagen fibers, aortic aneurysm, arachnodactyly, etc.); Wilson-Konovalov's disease (brain damage, large-nodular liver cirrhosis, hyperpupuria); Ehlers-Danlo syndrome (hereditary mesenchymal dysplasia associated with deficiency of lysyloxidase).

Primary (idiopathic) emphysema of the lungs

Medi-deficient collagen and elastopathy (aortopathy, arteriopathy, aneurysm)

Medi-deficiency diseases of the skeleton and joints

Mede-deficiency anemia of nutritional origin

Medi-deficiency states with complete parenteral nutrition (anemia)

Nonspecific hypercompumia in acute and chronic inflammatory diseases, rheumatism, bronchial asthma, kidney disease, liver, MI and some malignant neoplasms, blood diseases: leukemia, lymphogranulomatosis, hemochromatosis, large and small thalassemia, megaloblastic and aplastic anemia

Professional hyperkupreosis (copper fever, pneumoconiosis)

Poisoning with copper-containing drugs

Hemodialysis hypercupriosis Use of oral contraceptives, estrogens

trusted-source [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]

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