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Causes of copper deficiency in the blood
Medical expert of the article
Last reviewed: 23.04.2024
Inadequate intake of copper in the body of children underlies 3 clinical syndromes.
- Anemia (in infants, when they are fed mostly with dry or fresh cow's milk), anorexia and a low copper content in the blood.
- Neutropenia, chronic or intermittent diarrhea, decreased copper concentration and ceruloplasmin activity in the blood, impaired calcification of bones, anemia (due to a violation of iron ferritin use).
- Syndrome Menkes (the result of a genetically determined defect in copper absorption).
Metabolic disorders with copper deficiency
| Pathology | Metabolic Defect | Insufficient enzyme |
| Achromotrihia | Disturbance of melanin synthesis | Tyrosinase |
| Violations of the formation of the cardiovascular system, skeleton, collagen and elastin | Violation of the formation of "stitching" of collagen and elastic fibers | Amino oxidase of connective tissue (lysyloxidase) |
| CNS lesion | Myelin hypoplasia | Cytochrome-C-oxidase |
|
CNS lesion |
Violation of the synthesis of |
Dopamine-.beta.-hydroxylase |
The most important diseases, syndromes, signs of deficiency and excess of copper
| Deficiency of copper in the body | Excess of copper in the body |
|
Hereditary forms of hypo- and sporopreosis: Menkes disease (illness of "curly hair" with severe CNS damage); Marfan syndrome (skeletal anomalies, elastic and collagen fibers, aortic aneurysm, arachnodactyly, etc.); Wilson-Konovalov's disease (brain damage, large-nodular liver cirrhosis, hyperpupuria); Ehlers-Danlo syndrome (hereditary mesenchymal dysplasia associated with deficiency of lysyloxidase). Primary (idiopathic) emphysema of the lungs Medi-deficient collagen and elastopathy (aortopathy, arteriopathy, aneurysm) Medi-deficiency diseases of the skeleton and joints Mede-deficiency anemia of nutritional origin Medi-deficiency states with complete parenteral nutrition (anemia) |
Nonspecific hypercompumia in acute and chronic inflammatory diseases, rheumatism, bronchial asthma, kidney disease, liver, MI and some malignant neoplasms, blood diseases: leukemia, lymphogranulomatosis, hemochromatosis, large and small thalassemia, megaloblastic and aplastic anemia Professional hyperkupreosis (copper fever, pneumoconiosis) Poisoning with copper-containing drugs Hemodialysis hypercupriosis Use of oral contraceptives, estrogens |
[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13]