Bicarbon

Various medications are used to treat functional gastrointestinal disorders, but Bekarbone deserves special attention. We will become acquainted with this preparation in more detail. Bicarbon is a combined drug with spasmolytic and antacid action. Tablets contain two active components: belladonna extract and sodium hydrogen carbonate. It is this pharmacological composition that provides a stable therapeutic effect. Before starting therapy, it is recommended to consult a doctor.

[1], [2], [3], [4], [5], [6], [7]

Indications Bicarbon

In order for the treatment to be as effective and effective as possible, all medicines must be taken only for medical purposes.

Indications for use:

• Functional disorders of the gastrointestinal tract
• Spasms of the intestines and bile ducts
• Heartburn
• Hyperacid gastritis
• Dyspepsia
• Stomach ache
• Gastrointestinal smooth muscle spasms

Bicarbon can be used in the complex therapy of the above diseases in combination with other medicines.

[8], [9], [10], [11], [12]

Release form

Spasmolytic has a tablet form of release. In one package, two blisters for 10 tablets each. The tablets are yellow-brown in color. Each capsule contains 0.01 g of belladonna extract and 0.3 g of sodium bicarbonate, auxiliary substances: starch and talc.

[13], [14], [15], [16]

Pharmacodynamics

The composition of the drug includes two active substances, which differ in efficiency and principle of action. Pharmacodynamics of bicarbon:

• Extract krasavki enters the category of M-holinoblokatorov and has spasmolytic effect. The substance inhibits acetylcholine, provoking a decreased secretion of gastric juice, bronchial mucus, salivary glands. Belladonna inhibits sweating and secretion of the tear duct, but produces the secret of the pancreas. Supports muscle hypotension of the gallbladder and its ducts, organs of the digestive tract. May provoke the development of mydriasis, tachycardia, increased intraocular pressure and difficulty in tearing.
• Sodium bicarbonate refers to antacids, that is, neutralizers of increased acidity. Getting into the body, the component comes into contact with hydrochloric acid, which is contained in the gastric juice. Such interaction accelerates the excretion of chlorine and sodium from the body, promotes osmotic diuresis, hypersecretion of bronchial mucus. Hydrocarbonate has expectorant and mucolytic properties.

[17], [18], [19], [20], [21], [22], [23], [24], [25]

Pharmacokinetics

After ingestion, the drug is absorbed into the digestive tract, providing a therapeutic effect. Tablets should be taken before meals, as food slows down absorption. Pharmacokinetics is based on the activity of the constituents of bicarbon.

Spasmolytic effect occurs within 30 minutes after application, as well as hypoxecretory action. The activity of the drug is maintained for 5-6 hours after taking the recommended single dose. It is excreted by the kidneys in the form of inactive metabolites and with feces, the binding to blood plasma proteins is low.

[26], [27], [28], [29], [30], [31], [32]

Dosing and administration

Based on the results of tests and diagnosis of the patient's condition, the doctor selects the method of application and dose of the drug. As a rule, appoint 1 tablet 2-3 times a day for 30-40 minutes before meals. The maximum daily dose should not exceed 5 tablets. Capsules can not be chewed, they are swallowed, washed down with water.

The pharmaceutical is intended for short-term symptomatic treatment, so the duration of therapy should be controlled by a physician. If the negative signs of the disease did not disappear after 3-5 days, then the treatment regimen and further use of the drug are reviewed.

[42], [43], [44], [45], [46], [47]

Use Bicarbon during pregnancy

Bicarbon is not prescribed for the treatment of functional disorders of the gastrointestinal tract in expectant mothers. That is, its use during pregnancy and lactation is contraindicated. The application is possible if the therapeutic benefit for the mother is higher than the potential risks to the fetus.

With special care, tablets are taken when driving vehicles and other mechanisms, since side effects from the organs of vision and the nervous system are possible. The drug is not prescribed for the treatment of children of childhood.

Contraindications

The main contraindication to the use of bicarbonate is the individual intolerance of its active ingredients. Tablets are not taken at:

• Diseases of the cardiovascular system (tachycardia, ischemia, arterial hypertension, arrhythmia)
• Retention of urine
• Diseases of the gastrointestinal tract with obstruction
• Hypoacid gastritis
• Glaucoma
• Acute bleeding
• Myasthenia gravis
• Thyrotoxicosis

With special care, medication is prescribed with weakened immunity, increased temperature, for elderly patients and in the presence of such disorders:

• Vegetative Neuropathy
• Hypertrophy of the prostate
• Cerebral paralysis
• Down's disease
• Chronic and acute lung disease
• Renal and hepatic impairment
• Reflux-esophagitis
• Hernia of the esophageal opening of the diaphragm
• Inflammation of the intestine

The drug is not recommended to be used longer than the doctor's appointed time, as this can cause negative symptoms and worsen the course of the underlying illness.

[33], [34], [35], [36]

Side effects Bicarbon

If the medical recommendations on the use of a combined agent for the treatment of functional disorders of the gastrointestinal tract are not observed, side effects appear. Most often, the disturbances are manifested by the nervous system, causing headaches, nervousness, dizziness, sleep disorders, speech disorders. Possible problems with urination, impaired taste, belching, abdominal pain, constipation, a decrease in intestinal motility.

In rare cases, adverse reactions cause photophobia, increased intraocular pressure, flushing of the face, palpitations. In addition, hypersensitivity reactions, anaphylactic shock, skin rashes, dermatitis are possible. When the above symptoms appear, you should stop taking Bicarbon and seek medical help.

[37], [38], [39], [40], [41]

Overdose

Long-term use of the drug or exceeding the recommended dose, provokes negative symptoms. Overdosing manifests itself as an increase in adverse reactions. Patients face nausea and vomiting, palpitations, irritability, sleep problems, headaches, cramps.

Symptomatic therapy is used to eliminate these symptoms. It is recommended to take activated charcoal, wash the stomach and correct the water-electrolyte balance. 

[48], [49], [50], [51], [52], [53], [54]

Interactions with other drugs

For a speedy recovery, patients are prescribed complex therapy, which consists of the use of several drugs simultaneously. The interaction of Bacarbon with other drugs should be controlled by a physician. Let's consider possible reactions of an antispasmodic with other means:

• Anticholinergic action is enhanced when used with Amantadine, Glutetimide, Nefopam.
• Oppression of the central nervous system and inhibition develop with the use of opioid analgesics and fengtiazines.
• Increased intraocular pressure - the use of haloperidol, betirophenon, corticosteroids.
• Orthostatic hypotension develops when combined with Furosemide.
• Interaction with non-steroidal anti-inflammatory drugs: Digitoxin, Metronidazole, Doxycycline, Griseofulvin causes a decrease in their effectiveness.
• Ketoconazole increases the pH of gastric juice, so it must be taken two hours before bicarbonate.
• Sodium bicarbonate can increase the excretion of lithium and reduce its concentration in the blood plasma.

[55], [56], [57], [58], [59], [60]

Storage conditions

In order for the treatment to be effective, it is very important to observe the storage conditions of the drug. Bicarbonate should be kept in its original packaging, protected from moisture, sunlight and inaccessible to children. Recommended storage temperature is within 25 ^o C.

If the above storage conditions are not observed, the tablets lose their medicinal properties and are prohibited for use.

[61], [62], [63], [64], [65]

Shelf life

Bicarbonate is allowed to take within 36 months from the production date. Shelf life is indicated on the package of tablets. After its expiration, the medicine must be disposed of. Since application can cause uncontrolled adverse reactions from many organs and systems, which will worsen the course of the underlying disease.

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