Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Analysis for hepatitis E: IgG and IgM antibodies to HEV in the blood

Medical expert of the article

Hepatologist
, medical expert
Last reviewed: 11.04.2020

Viral hepatitis E causes the hepatitis E virus (HEV) - an RNA-containing virus. The disease is characterized by a fecal-oral route of transmission, predominantly aquatic. The incubation period of the disease is about 35 days. The clinical course of acute viral hepatitis E is similar to the course of viral hepatitis A. Much heavier the disease occurs in pregnant women, especially in the third trimester. RNA HEV appears in the blood 2-3 weeks after infection. Viralemia indicates the fact of infection and lasts on average for 3 months, less often - up to 6 months.

For specific diagnostics of viral hepatitis E, the ELISA method based on the detection of IgM antibodies (anti-HEV IgM), which appears in the blood 3-4 weeks after infection (10-12th day from the onset of clinical manifestations of the disease) is used. Detection of anti-HEV IgM in the blood serves as a laboratory confirmation of the diagnosis. They are detected in 90% of patients with acute infection within 1-4 weeks from the onset of the disease. Anti-HEV IgM disappear from the blood for several months. After 3 months from the onset of the disease, antibodies are detected only in 50% of patients, and after 6-7 months - in 6-7%. IgG antibodies in viral hepatitis E are detected in the blood at the height of the disease, during recovery they reach the highest values (detectable in 93-95% of patients). The presence of only IgG antibodies can not be considered a confirmation of the diagnosis of viral hepatitis E.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9],


The iLive portal does not provide medical advice, diagnosis or treatment.
The information published on the portal is for reference only and should not be used without consulting a specialist.
Carefully read the rules and policies of the site. You can also contact us!

Copyright © 2011 - 2021 iLive. All rights reserved.