Analyzes for hormones

Thyroid-stimulating hormone in the blood

To determine the content of thyroid-stimulating hormone in the serum, use RIA, ELISA and immunofemiluminescent analysis. The latter method is based on the use of monoclonal antibodies to the thyroid-stimulating hormone and the enhancement of chemiluminescence, its sensitivity is two orders of magnitude greater than the sensitivity of RIA and one order of magnitude - ELISA.

Functional state of the thyroid gland

Diseases of the thyroid gland by prevalence are the second most endocrine diseases after diabetes mellitus. They develop as a result of violations of the regulation of thyroid function, changes in the biosynthesis of thyroid hormones or their action in tissues.

17-Ketosteroids in the urine

Urine ketosteroids are metabolites of androgens secreted by the mesh cortex of the adrenal cortex and the sex glands. Only a small fraction of the 17-ketosteroid urine is derived from the precursors of glucocorticosteroids (approximately 10-15%). The determination of 17-ketosteroids in urine is necessary to assess the overall functional activity of the adrenal cortex.

17alpha-hydroxyprogesterone in the blood

17-Hydroxyprogesterone is a precursor of cortisol, which has a natriuretic effect. The hormone is produced in the adrenal glands, ovaries, testicles and placenta. As a result of hydroxylation of 17-hydroxyprogesterone is converted to cortisol.

Dehydroepiandrosterone sulfate in the blood

Dehydroepiandrosterone sulfate is synthesized in the adrenal glands (95%) and in the ovaries (5%), excreted in urine and constitutes the main fraction of 17α-ketosteroids. The determination of its concentration in the blood replaces the study of 17α-ketosteroids of urine.

Androstenedione in the blood

DHEA - the main androgen (more precisely, their predecessor), produced by the adrenal glands. Most of DHEA is rapidly modified by the addition of sulfate, about half of DHEA is sulfated (formed by DHEAS) in the adrenal glands, and the remainder in the liver.

17-Oxycorticosteroids in urine

17-Oxycorticosteroids include glucocorticosteroids and their metabolites. Excretion of 17-oxycorticosteroids is decreased in patients with chronic adrenocortical insufficiency.

Free cortisol in the urine

Free cortisol (not associated with blood plasma proteins) is filtered in the renal glomeruli and excreted in the urine. Free cortisol in blood plasma is the main biologically active form of the hormone.

Cortisol in the blood

Cortisol is a steroid hormone secreted by the adrenal cortex. It is 75-90% of the corticosteroids circulating in the blood, is metabolized in the liver. The half-life is 80-100 min. Cortisol is filtered in the renal glomeruli and is removed with urine.

Adrenocorticotropic hormone in the blood

Adrenocorticotropic hormone is a peptide consisting of 39 amino acid residues with a molecular mass of approximately 4500. The secretion of ACTH into the blood is subject to circadian rhythms, the concentration is maximal at 6 o'clock in the morning, and the minimum is about 22 hours. Strong ACTH stimulator is stress. The half-life in the blood is 3-8 minutes.

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