Allochol

Allochol is a combined choleretic drug.

[1]

Indications Allochol

Indications for use

• These pills from abdominal pain are used for chronic hepatitis, cholangitis, cholecystitis.
• Used for dyskinesia of the gallbladder and biliary tracts, as well as for postcholecystectomy syndrome.
• Indicated for use with atopic constipation. 

Release form

Allochol is produced in tablets, which are covered with a shell, which has a coloring from yellow-green to orange. The surface of the tablet is biconvex. If the tablet is broken across, then a core is found in the fault, which is surrounded by two layers of shells.

One tablet contains active ingredients: bile condensed or bile dry - eighty milligrams, powder from dried garlic - forty milligrams, nettle leaves - five milligrams, activated carbon - twenty five milligrams. Of the excipients in the tablet contains a certain amount of magnesium oxide, potato starch, aerosil, calcium stearate, sugar, povidone, magnesium carbonate basic, titanium dioxide, talc, tropeoline O or tartazan, beeswax, vaseline oil.

Tablets from abdominal pain are placed in ten pieces in a contour mesh package. Five such packages are located in a cardboard bundle, provided with an insert instruction.

Pharmacodynamics

Allochol helps improve the secretory function of liver cells, which leads to a moderate choleretic effect. Allochol leads to stimulation of production of bile acids, and also leads to an increase in the osmotic gradient between bile and blood. All of the above increases the filtration of water and electrolytes in the bile capillaries. Also, the drug has an accelerating effect on the course of bile along the bile ducts, which helps to prevent the spread of ascending infections and reduces the activity of inflammatory processes. Allochol has the ability to reduce the deposition of cholesterol in the sediment, which is the prevention of stone formation in the gallbladder. Dry bile contributes to the improvement of the process of cholate formation, namely, the taurocholic and deoxycholic acids present in its composition. More bile, released into the intestinal lumen, leads to a reflex increase in secretion and motor activity in the digestive system, and also improves the quality of fat emulsification and the entire digestive process. Dry garlic powder inhibits the processes of fermentation of the intestinal tract, which contributes to the elimination of symptoms of flatulence.

Pharmacokinetics

Allochol has the quality of good absorption in the intestinal tract of the digestive system, which leads to the rapid inclusion of its active components in the processes of hepatoduodenal circulation. Metabolism of choloidal and chenodeoxycholic acid is carried out in the intestine. Chenodeoxycholic acid is also metabolized in the liver. In this organ, it is conjugated to various amino acids, secreted into bile, along with which it again enters the intestinal part, where it partially undergoes reabsorption, and the other part of the acid is removed from the body with the help of feces.

[2], [3]

Dosing and administration

The drug is used after eating. Adults are recommended to take one or two tablets of Allochol three or four times a day. The course of treatment is from three to four weeks. If therapy needs to be continued, then the medication is taken one tablet two to three times a day for one or two months.

On the recommendation of a specialist, the course of treatment is repeated two to three times with a break in therapy, which lasts for three months.

Use Allochol during pregnancy

There are no data on the safe properties of Allochol in pregnancy and lactation. Leaves of nettle can lead to the emergence of uterotonic effect. Therefore, it is possible to use the medicine in the above periods only for the vital indications for the woman, when the benefit to the mother exceeds the risk of problems in the fetus or the child, and under the supervision of a specialist.

Contraindications

• Presence of hypersensitivity to drug substances.
• The history of acute hepatitis, cholelithiasis, obstructive jaundice, acute or subacute hepatic dystrophy.
• The patient's spasm of sphincter Oddy, acute pancreatitis, acute ulcer of the stomach and duodenum, acute enterocolitis. 

[4], [5], [6], [7], [8], [9], [10], [11]

Side effects Allochol

• The appearance of diarrhea.
• The occurrence of allergic reactions in the form of reddening of the skin, rash, itching of the skin.
• If there are allergic manifestations, then it is necessary to cancel the use of Allochol and take advantage of desensitizing therapy.

[12], [13], [14], [15]

Overdose

Overdose is possible in case of application of Allochol in large quantities exceeding the permissible instructions. Also, overdose symptoms can occur with prolonged use of medication doses that exceed the largest daily dose.

In this case, there are signs of diarrhea, nausea, pruritus, transaminases in the blood increase.

In this case, you need to cancel Allochol and take symptomatic therapy.

There is no specific antidote to the drug.

[16],

Interactions with other drugs

There is no description of the negative manifestation of the action of Allocholum with its simultaneous use with other medicines.

It is not recommended to use Allochol simultaneously with drugs containing aluminum, cholestyramine, cholestipoles, as this leads to a decrease in absorption and a decrease in therapeutic effect.

Simultaneous use of Allochol and choleretics with a synthetic or plant nature leads to an increase in the choleretic effect. Allochol can lead to an increase in the effect of laxatives. Allochol has a stimulating effect on fat-soluble vitamins, which are better absorbed into the intestines.

With the simultaneous administration of Warfarin and the use of garlic, which is present in the composition of the drug, there is a possibility of an increase in the period of bleeding.

[17], [18], [19], [20], [21]

Storage conditions

Allochol - the medicine should be kept in a place that is protected from moisture, light and penetration of children at a temperature not exceeding 25 ° C.

Shelf life

Allochol is stored for 4 years from the date of manufacture.