Allergodil

Allergodil has antiallergic and antihistamine effects.

After instillation of the medicine into the nose, congestion is relieved, and the volume of nasal discharge and frequency of sneezing are reduced. The symptoms of the disease are relieved after 15 minutes from the moment of using the medicine; the therapeutic effect continues for 12+ hours. [ 1 ]

In case of eye drops, an additional anti-inflammatory effect develops. The systemic effect with local use is weak.

Indications Allergodil

The nasal spray is used for such disorders as seasonal or non-seasonal rhinitis (allergic in nature) and vasomotor rhinitis.

Eye drops are used in the following cases:

• seasonal form of conjunctivitis of allergic origin;
• inflammations of various origins affecting the eyes (also post-traumatic);
• allergic form of conjunctivitis of a year-round nature.

Release form

The drug is released in the form of 0.05% eye drops - inside a bottle equipped with a dropper, with a volume of 6 or 10 ml.

In addition, it is sold in the form of a nasal spray, equipped with a dispenser-atomizer, inside 10 ml bottles.

Pharmacodynamics

The drug selectively blocks the activity of H1-endings.

It has a membrane-stabilizing and antihistamine effect, strengthens the strength of capillaries, and also prevents the release of active elements (leukotrienes, histamine and serotonin) from labrocytes that cause bronchial spasms and allergy symptoms. [ 2 ]

Pharmacokinetics

After nasal administration, the bioavailability of the drug is 40%. Over a period of 2-3 hours, the blood index of the drug reaches Cmax values, which are 8 times lower than the level recorded after experimental oral administration. In people with allergic rhinitis, the Allergodil index exceeds the values observed in a healthy person.

When using eye drops (4 times a day, 1 drop each time), the plasma level of the drug is extremely low.

Dosing and administration

Nasal spray usage patterns.

The spray bottle is equipped with a dispenser-sprayer, which makes its use much easier. Before the first administration procedure, the medicine should be sprayed into the air. It is necessary to spray the required amount of spray into each nostril, while keeping the head straight.

For rhinoconjunctivitis and allergic rhinitis: for children over 6 years of age and adults, use 1 portion (1 spray) in each nostril, in the morning and in the evening. For people over 12 years of age, the dosage can be increased to 2 portions of the medicine 2 times a day. The drug should be used until the signs of the disease disappear. Allergodil can be used for a long time, but in a continuous mode - a maximum of 5-6 months.

For rhinitis of vasomotor nature: for a child over 12 years old and an adult, 2 doses of the drug are required in each nostril 2 times a day. The drug is also used until the manifestations of the pathology disappear. The duration of continuous therapy for this disease can be a maximum of 2 months.

Schemes for the use of eye drops.

The medication is instilled into the conjunctival sac.

For seasonal allergic conjunctivitis: for a child over 4 years old and an adult, 1 drop of the medicine is required in both eyes 2 times a day (morning and evening). If necessary, the medicine can be used up to 4 times a day. With this pathology, the medicine can be used exclusively for prevention.

To treat the allergic form of non-seasonal conjunctivitis, a child over 12 years of age and an adult should instill 1 drop of the medicine into each eye 2 times a day. A dosage of 1 drop can be used up to 4 times a day.

• Application for children

The medicine in the form of a spray is not used in persons under 6 years of age, and drops are not used in persons under 4 years of age.

Use Allergodil during pregnancy

It is prohibited to use the medicine during pregnancy.

Contraindications

Among the contraindications:

• pronounced sensitization to the drug and its components;
• breastfeeding period;
• The nasal spray cannot be used in case of kidney failure.

Side effects Allergodil

When using drops, the following side effects may be observed:

• swelling, irritation, redness, increased lacrimation, itching and pain in the eye area;
• sensation of a foreign object and hemorrhage in the eye area;
• dry eye mucosa, visual impairment and blepharitis;
• Systemic manifestations are occasionally observed – problems with defecation and difficulty breathing.

The use of the spray can provoke the following disorders:

• itching or burning and bleeding from the nose, as well as sneezing;
• if the medicine is used with the head tilted back and the substance enters the nasopharynx, nausea may occur;
• epidermal itching and rashes;
• gastralgia and xerostomia;
• dizziness and feeling of weakness;
• a feeling of tightness in the chest area.

Interactions with other drugs

The drug potentiates the sedative effect of substances that suppress the activity of the central nervous system and ethyl alcohol.

Combination with cimetidine increases plasma levels of the active component Allergodil, while with ketoconazole, on the contrary, it decreases them.

Storage conditions

Allergodil should be stored at a temperature between 8-25°C. Freezing the medication is prohibited.

Shelf life

Allergodil can be used for a period of 36 months from the date of manufacture of the pharmaceutical product.

Analogues

Analogues of the drug are eye drops Azelastine hydrochloride, as well as nasal spray Allergodil S.