Aecol

Aekol is a medicine used to treat ulcers and wounds - it helps them to scar and heal.

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Indications Aecol

It is used in the complex treatment of ulcers of the duodenum and stomach, as well as non-specific ulcerative colitis and conditions after gastric resection.

It is also indicated locally: for healing cracks in the rectal mucosa (also in conditions after operations to cut out cracks), in hemorrhoids, proctosigmoiditis, trophic, decubital or varicose ulcers, as well as in scleroderma, erosion of the cervix and colpitis. Also for the treatment of endocervicitis, purulent-necrotic wounds, infected burns (2-3 degrees) and conditions after autodermoplasty.

Release form

It is produced as an oil solution in 50 or 100 ml bottles. One package contains 1 bottle.

Pharmacodynamics

A combined vitamin complex, the properties of which are determined by the action of the components contained in its composition (retinol, tocopherol and vitamin K). The medicine has an antiulcer and metabolic effect, and in addition, it stimulates reparative processes and accelerates wound healing. It also has an anti-inflammatory and antioxidant effect, and in addition, it restores the process of blood circulation in the capillaries, stabilizes their permeability and tissue permeability. In addition, it has hemostatic properties.

Dosing and administration

The medicine should be taken orally, before meals (30-40 minutes). For adults, the dosage is 5-10 ml (or 1-2 teaspoons) 2-3 times a day for 4-5 weeks.

If necessary, after a preliminary medical consultation, the treatment course may be repeated after six months.

In proctology it is used locally - in this case either tampons soaked in the solution or microclysters of 30-50 ml are used for 10-12 days. In gynecology tampons soaked in the solution are also used. The course duration is 1-15 treatment procedures.

In case of skin lesions, it is applied to the injured areas, which must first be cleaned of any necrotic formations that have appeared on them. It is applied in the form of oil dressings until epithelialization with granulation appears.

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Use Aecol during pregnancy

Oral administration of the drug during breastfeeding and pregnancy is prohibited.

Contraindications

It is prohibited to use the medicine locally if there is an individual intolerance to the components of the drug.

Contraindications for oral administration:

• children under 14 years of age;
• hypervitaminosis types A and E;
• retinoid overdose;
• the presence of obesity or thyrotoxicosis;
• stage of exacerbation of myocardial infarction;
• severe form of cardiosclerosis;
• decompensated heart failure;
• cholelithiasis;
• chronic pancreatitis or severe stage of liver failure;
• chronic form of glomerulonephritis;
• acute or chronic stage of nephritis;
• hyperlipidemia or hypercoagulation;
• presence of thromboembolism;
• chronic form of alcoholism;
• Besnier-Böck-Schaumann disease (also in the anamnesis);
• G6PD deficiency.

Side effects Aecol

As a result of using the drug, the following side effects may develop:

• nervous system organs: a feeling of lethargy, drowsiness or weakness, rapid fatigue, a feeling of irritability, insomnia, headaches, a feeling of discomfort and the development of convulsions. In addition, visual or taste disturbances, increased intraocular pressure, profuse sweating, an increase in temperature, and a feeling of heat are possible;
• musculoskeletal system: disturbances in gait, pain in the leg bones, bone changes observed on X-rays;
• gastrointestinal tract: loss of appetite, dry mouth, appearance of aphthae, dyspepsia with a feeling of discomfort in the epigastrium, pain in the abdomen, vomiting with nausea, diarrhea, weight loss;
• (an exacerbation of liver pathologies may be observed, as well as an increase in the activity of liver transaminases and alkaline phosphatase).
• urinary system organs: development of nocturia, pollakiuria or polyuria;
• organs of the hematopoietic system: hemolytic form of anemia, development of hyperprothrombinemia or hyperthrombinemia, and in addition thromboembolism. Also in patients with tocopherol deficiency, hematolysis is possible;
• cardiovascular system: development of tachycardia, temporary decrease in blood pressure, weak pulse;
• allergies: development of urticaria or erythema, skin rash, itching, dryness and peeling. In addition, there may be bronchial spasms, facial hyperemia, cracks in the skin of the lips, yellow-orange spots may appear on the palms, soles and in the nasolabial triangle. Swelling under the skin may also appear. Single occurrences on the 1st day of use may include the appearance of a maculopapular rash that itches (in this case, the use of the drug should be discontinued). Reactions at the site of application of the drug are also possible;
• Others: alopecia, menstrual irregularities, development of hyperbilirubinemia or hypercalcemia, and photophobia.

After reducing the dosage or temporarily stopping the use of the drug, the side effects go away on their own.

In case of skin diseases, using the medicine for 7-10 days in high doses can provoke an exacerbation of local inflammatory processes (additional treatment is not necessary in this case, the symptoms go away over time). This effect develops due to the immuno- and myelostimulating properties of the drug.

As a result of prolonged use of tocopherol in large daily doses (400-800 mg), hypothrombinemia may increase. In addition, creatinuria, dizziness, and bleeding in the gastrointestinal tract may also be observed.

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Overdose

Signs of a drug overdose include manifestations of hypervitaminosis types A, E or K.

Overdose of retinol: a feeling of irritability, dizziness or confusion, as well as diarrhea and severe dehydration. A generalized rash on the skin is also possible, which then begins to peel in large layers, starting from the face. In addition, bleeding gums, dryness of the oral mucosa and the appearance of ulcers on it, as well as peeling of the skin on the lips may be observed. When palpating long tubular bones, sharp pain may be felt (due to subperiosteal hemorrhages).

Acute or chronic hypervitaminosis A manifests itself in the form of severe headaches, increased temperature, vomiting, drowsiness, vision problems (double vision begins), dry skin and pain in the muscles and joints. In addition, the size of the spleen and liver may increase, pigment spots may appear, jaundice may develop; the blood picture may change, appetite may disappear and loss of strength may be observed. In severe cases of the disease, seizures begin, heart weakness appears, and hydrocephalus develops.

In these cases, symptomatic therapy is required.

As a result of taking an increased dose of tocopherol (400-800 mg per day over a long period of time), a general feeling of weakness, headaches, dyspeptic symptoms and a feeling of fatigue may develop. It is also possible to increase the risk of thromboembolism in people with a predisposition to this disease. In addition, the cholesterol level may increase.

To eliminate the symptoms, it is necessary to remove tocopherol from the body, and then symptomatic treatment is carried out.

In case of development of hypervitaminosis type K, hyperprothrombinemia or hyperthrombinemia, or hyperbilirubinemia occurs, and in addition, jaundice may develop and the activity of liver transaminases may increase. Constipation, diarrhea, abdominal pain, skin rash, and in addition, a feeling of general overexcitement are also possible.

Treatment requires discontinuing the medication. Anticoagulants are prescribed, which must be taken while monitoring the blood coagulation system. Symptomatic therapy is also performed.

Interactions with other drugs

The drug is prohibited to be taken orally together with estrogens (this increases the risk of hypervitaminosis type A), and also with cholestyramine and nitrites, because they prevent the absorption of Aekol.

It cannot be combined with indirect anticoagulants, or with silver or iron agents.

Retinol should not be combined with aspirin and hydrochloric acid. In addition, it weakens the anti-inflammatory properties of GCS.

When retinol is combined with vaseline oil, the absorption of the vitamin in the intestines may be disrupted.

Tocopherol promotes rapid absorption and assimilation of retinol. It should be taken into account that large doses of tocopherol can provoke a deficiency of retinol in the body.

Tocopherol increases the effectiveness of the medicinal effect of steroid drugs and NSAIDs (such as ibuprofen, sodium diclofenac, and prednisolone), and also reduces the toxic effect of cardiac glycosides (such as digitoxin with digoxin) and vitamin D with retinol. Cholestyramine, as well as colestipol with mineral oils, reduce the absorption of tocopherol.

Tocopherol may enhance the effects of anticonvulsants in patients with epilepsy who have elevated levels of lipid peroxidation products in their blood. Tocopherol and its breakdown products are vitamin K antagonists.

Phylloquinone weakens the effect of indirect anticoagulants (including coumarin derivatives and indandione). It does not affect the anticoagulant activity of heparin. When combined with fibrinolysis inhibitors and aggregators, their hemostatic effect is enhanced.

When combined with antibiotics with a broad spectrum of action, and also with salicylates (in high doses), quinine and quinidine, as well as sulfonamide drugs, it is necessary to increase the dosage of phylloquinone.

Antacid drugs slow down the absorption of the vitamin because bile salts settle in the upper part of the small intestine. Cholestyramine with colestipol, as well as mineral oils, dactinomycin and sucralfate also slow down the absorption of vitamin K.

When combined with hemolytic drugs, the risk of developing adverse reactions increases.

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Storage conditions

The medicine must be kept in standard conditions for medicines - inaccessible to children, dry, dark place. Temperature - maximum 25°C.

Shelf life

Aekol is permitted to be used for 2 years from the date of manufacture of the medicine.