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Adenorm is a drug from the group of selective adrenoreceptor blockers such as α-1D and α-1A.
The active substance of the drug is tamsulosin hydrochloride, which blocks the postsynaptic adrenoreceptors of the α-1D and α-1A groups in the smooth muscles of the prostate, the neck of the ureter, and the prostatic area of the urethra. Under the influence of the drug, smooth muscles relax, there is an improvement in detrusor functioning, and irritation and obstruction, which result from benign prostatic hyperplasia, disappear. Adenorm does not cause systemic BP changes even in those patients who suffer from hypertension. The maximum therapeutic effect of this drug reaches 2 weeks after the start of therapy.
After internal administration, tamsulosin is rapidly absorbed into the digestive tract. The maximum saturation in the blood plasma the active component reaches 6 hours after a single dose. The drug has high rates of binding to plasma proteins (up to 99%). Metabolism of tamsulosin occurs in the liver. In the process, metabolites with a weaker pharmacological effect are formed.
After a single use, the half-life is 10 hours. If the medication is regular, the half-life of the active substance is increased to 13 hours. The drug is excreted through the kidneys, most often under the guise of metabolites. A maximum of 10% of the substance is unchanged.
Among the contraindications:
- High individual sensitivity to individual elements of the drug;
- Patients undergoing a therapeutic course due to a violation of liver activity in severe form, as well as patients who have an anamnesis with orthostatic collapse.
With special care, it is necessary to appoint Adenorm to people with functional impairment of the kidneys (patients with a rate of purification of creatinine less than 10ml / minute).
Side effects of the adenorm
In general, the drug is tolerated by patients without complications, but in some cases, as a result of its use, such adverse reactions were observed:
- Organs of the cardiovascular system: heart rhythm disturbances, fainting, orthostatic collapse;
- CNS organs: weakness in muscles, headaches;
- Allergies: itching and rash on the skin, as well as hives.
Dosing and administration
The medicine is for internal reception. Capsule can not be chewed or crushed - you need to swallow whole, after washing with ordinary water. The use of the drug is not related to meals.
The duration of the treatment course, as well as the dosage is assigned to patients individually - this should be done by the doctor in charge. For adults, the dose is usually 1 capsule 1 rub. / Day.
Interactions with other drugs
In combination with drugs from the category of α 1 -adrenoreceptor blockers can cause a decrease in blood pressure.
With the joint adenorma and cimetidine, a slight increase in the saturation of tamsulosin in the blood plasma occurs.
During the interaction of the drug with furosemide, a slight decrease in the saturation of the active element in the plasma is observed.
When Adenorm is combined with warfarin, as well as diclofenac, the half-life of tamsulosin decreases.
To simplify the perception of information, this instruction for use of the drug "Adenorm" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.