Abiflox

Abiflox is an antimicrobial drug of the fluoroquinolone group. It has an inhibitory effect on the DNA hydrase and topomerase IV complex, which disrupts the synthesis of microbial cells and causes the destruction of the infectious agent. Abiflox does not have cross-resistance between other groups of antimicrobial agents, but has between the fluoroquinolone groups.

Indications Abiflox

The following indications for the use of Abiflox are distinguished:

• Inflammations caused by microorganisms that are sensitive to levofloxacin;
• Inflammation of the bronchopulmonary system (damage to the pleura, bronchi, lungs, etc.);
• Inflammation of the genitourinary tract (inflammation of the kidneys, prostate);
• Skin inflammations, as well as inflammations of soft tissues.

Release form

The drug is released in the following form: a solution for infusions with a volume of one hundred milliliters/five hundred milligrams in vials No. 1. 100 ml of solution contains 500 mg of levofloxacin (in the form of levofloxacin hemidrate). Additional substances included in the composition of abiflox: anhydrous glucose, disodium edetate, anhydrous citric acid, hydrochloric acid, water for injection.

Pharmacokinetics

After oral administration, the drug is rapidly and almost completely absorbed (food intake has virtually no effect on this process). Bioavailability is ninety-nine percent. It penetrates well into the lungs, bronchi, urogenital tract, polymorphonuclear leukocytes, and alveolar macrophages. Some of it is oxidized in the liver and can be deacetylated. It is eliminated from the body mainly through the kidneys. A small percentage of the active substance is excreted as metabolites. Seventy percent of abiflox is excreted unchanged in the urine within twenty-four hours, eighty-seven percent within forty-eight hours; four percent of the substance taken accumulates in the feces within seventy-two hours.

Dosing and administration

Method of administration and dosage of the drug: Abiflox is intended for slow infusion (one hundred milliliters of the substance are administered at least an hour before). The drug should be used within three hours after opening the bottle.

Recommended doses:

• Inflammation of the lung tissue - 500 mg once or twice a day;
• Inflammation of the urinary tract - 250 mg once a day;
• Inflammation of the prostate gland - 500 mg once a day;
• Inflammation of the skin and soft tissues – 500 mg once or twice a day.

After three to four days of treatment, it is recommended to switch to the oral form of the drug. Doses may be increased in cases of complications of the disease. A lower dosage may be prescribed to patients with impaired renal function. In each individual case, the dosage of the drug and the duration of treatment are determined by the doctor depending on the full picture of the disease.

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Use Abiflox during pregnancy

The use of abiflox during pregnancy, as well as during lactation, is prohibited due to the possibility of negative effects on the fetus, in particular, on the formation and development of its musculoskeletal system. When prescribing abiflox during lactation, breastfeeding should be interrupted for the duration of treatment.

Contraindications

Contraindications to the use of Abiflox include hypersensitivity to levofloxacin or other substances included in the fluoroquinolone group. The drug is not used for epilepsy, as well as for tendon reactions to the use of fluoroquinolones. The drug Abiflox is not prescribed to children, as well as nursing women and pregnant women. When treated with Abiflox, the patient is prohibited from driving any type of transport, since the drug can affect psychomotor reactions and the functioning of the visual and auditory organs.

Side effects Abiflox

The following side effects are possible when taking the drug Abiflox:

• The occurrence of a hypersensitivity reaction, in rare cases the development of anaphylactic shock, photosensitivity;
• Loss or deterioration of appetite;
• Problems with bowel movements;
• Pseudomembranous enterocolitis;
• The emergence of a parasitic fungus;
• Impaired liver function;
• Hepatitis;
• Hypoglycemic syndrome in patients with diabetes mellitus;
• Increased number of eosinophils, decreased number of leukocytes and platelets, neutrophils;
• Headache and dizziness;
• Sensation of ringing in the ears, hearing loss;
• Decreased or lost sense of taste and smell;
• Vision problems (rare);
• Mental and emotional disorders;
• Lesions of the nervous system;
• Neuroleptic extrapyramidal disorders;
• Increased heart rate, drop in blood pressure;
• Effect on myocardial repolarization;
• Impaired kidney function;
• Occurrence of bronchospasm (rare);
• Allergic pneumonitis;
• Pain in the joints;
• Muscle pain;
• Tendon injury;
• Local reactions to Abiflox: burning sensation, pain and redness on the skin.

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Overdose

An overdose of the drug Abiflox may lead to seizures, loss and impairment of consciousness, and an increase in the QT interval on electrocardiography. Symptomatic therapy is used to provide assistance in case of an overdose.

Interactions with other drugs

The interaction of Abiflox with other drugs may have a negative effect.

Among them are the following:

• Theophylline, nonsteroidal anti-inflammatory drugs - lowers the seizure threshold;
• Fenbufen - increases the amount of levofloxacin in the blood by thirteen percent;
• Probenecid, Cimetidine - the elimination of levofloxacin is slowed down by twenty-four to thirty-four percent;
• Cyclosporine - its half-life increases by thirty-three percent;
• Vitamin K antagonists - risk of bleeding.
• Antiarrhythmic drugs, tricyclic antidepressants, macrolide drugs – prolongation of the Q T interval;
• It is not advisable to use alkaline solutions and heparin together with Abiflox.

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Storage conditions

Storage conditions for Abiflox: store at a temperature of no more than twenty-five degrees Celsius. Avoid direct sunlight and freezing. Keep out of reach of children.

Shelf life

The shelf life of the drug is two years.