Dexamethasone is available in:
- in tablet form (0.5 mg each);
- in the form of a solution in ampoules for intramuscular and intravenous injections (4 mg / ml);
- in the form of eye drops;
- in the form of an eye suspension.
The dosage regimen is set individually, taking into account the indications, the patient's well-being and her reaction to the treatment.
In urgent emergencies, dexamethasone is administered intravenously slowly (either by jet injection or drip). In normal practice, the drug is more often administered in the form of intramuscular injections. For dilution of the solution for intravenous infusion using a physiological solution of NaCl, or 5% glucose solution.
Dexamethasone injections intramuscularly is prescribed in an individually selected amount: at first, a somewhat overestimated dose of the drug is administered, then this amount is gradually reduced to the optimal and extremely effective dose. The average dosage may be from 0.5 to 9 mg of the drug per day. The intravenous drip is used in case of premature onset of labor, when the aim is to open the infant’s lungs with an incomplete formation of the respiratory system. Sometimes additional administration of the drug may be required immediately before delivery.
How many times can you prick Dexamethasone during pregnancy? There is no definite answer to this question, since the appointment is always individual and is selected for each specific case separately. Some women are given a one-time medication, and in other situations, treatment is required throughout the entire period of pregnancy. Long-term treatment is usually carried out using a dexamethasone tablet form.
Tablets are taken in the morning or before bedtime, or twice a day, in an individually determined amount. The average single amount of the drug - ½ tablet. Such a treatment regimen is most often used, when at first a woman takes an excessive dosage, which is gradually reduced and, if necessary, reduced to "no." With the expected long period of treatment, intramuscular injections are first administered, then the patient is transferred to maintenance therapy with Dexamethasone tablets.
There is also a form of medication in the form of an ophthalmic solution. Dexamethasone eye drops are not prohibited during pregnancy, but they are used only if you have a medical recommendation: for iritis or iridocyclitis, bacterial conjunctivitis. Drops do not have systemic effects, and their local use does not harm pregnancy and the fetus. Apply Dexamethasone up to 3 times a day, 1-2 drops in the affected eye (unless the doctor has appointed otherwise).
In case of bronchitis, pneumonia, asthma, laryngeal edema, the doctor may recommend inhalation medication. Dexamethasone inhalation during pregnancy is allowed, but the procedures are performed under medical supervision, and the entire period of inhalation treatment should not exceed 7-10 days.
Eye drops, or suspension-drops, in some cases, it is allowed to drip into the nasal cavity - for example, during sinusitis, rhinopharyngitis, pollinosis. Dexamethasone in the nose during pregnancy can alleviate the course of allergic rhinitis, reduce inflammation and intoxication. However, such drops can not be applied more than 3 times a day, and more than seven days in a row. Moreover, the medication should not be used without valid indications - for example, in case of a common cold, when it is possible to use safer drugs.
Cancellation of treatment
Many women who have to take the drug for a long time are worried: how will Dexamethasone cancel during pregnancy? Indeed, this question is relevant, since it is impossible to stop treatment with this medicine abruptly. Dexamethasone is canceled as smoothly as possible, moving to ¼ from the usual dosage for 10 days. What is it for? The bottom line is that the human body independently produces hormones that are similar in structure to Dexamethasone. Against the background of drug treatment, the hormone's own production is suppressed: the principle of feedback is activated. With abrupt cancellation of therapy, the body does not have time to adapt to the disturbed hormonal status. As a result, hypocorticism develops. Manifestations of such a pathological condition consist in the fact that the previously present problems are quickly exacerbated, laboratory indicators deteriorate, and blood pressure drops are observed. To avoid all this, care must be taken to stop taking Dexamethasone.
Sometimes, when removing the threat of interruption, the medication is canceled, and then a repeated course of Dexamethasone is prescribed during pregnancy. This should not be frightening: repeated treatment may be offered approximately 3-4 weeks after the first and is considered safe.
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Dexamethasone at different stages of pregnancy
Let's summarize a little. Dexamethasone in clinical practice can be used in such situations:
- Danger to woman's life. Dexamethasone can be included in the resuscitation scheme with a strong allergic process, with cerebral edema, as well as in the event that another life-threatening condition develops (bronchospasm, a complicated attack of bronchial asthma).
- Risk of miscarriage. Dexamethasone in early pregnancy is prescribed to prevent premature termination of the gestation process, or to inhibit such interruption at the initial stage of its development (if hyperandrogenism becomes the cause of this pathology - increased production of male sex hormones).
- Danger of preterm labor. If there is a risk that the child will be born prematurely and will be premature, then Dexamethasone is connected to speed up the adaptation of the infant's respiratory system to an independent respiratory function.
- Disorders in the development of the fetus. Dexamethasone in late pregnancy will be prescribed without fail if the fetus is diagnosed with congenital intrauterine hyperplasia of the adrenal cortex. This is a relatively rare pathology that requires mandatory medical correction.
- Autoimmune disease in women. Dexamethasone is included in the schedule of appointments during pregnancy, if a woman has a complicated course of dermatosis, connective tissue diseases, rheumatoid arthritis, and severe endocrine disorders.
- Malignant pathology during pregnancy. Dexamethasone is used as a drug that inhibits the division of abnormal cells.
In some cases, the doctor includes in the treatment regimen Dexamethasone as a prophylactic agent, preventing the recurrence of autoimmune pathology. Such an appointment is considered not so much in terms of the negative impact on the course of pregnancy or fetal development, but in terms of preventing a sharp exacerbation of the disease, which can cause much greater damage than the use of the drug.
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