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Health

Nazivin

, medical expert
Last reviewed: 23.04.2024
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Medicinal medication Nazivin is intended for intranasal external use, for the treatment of rhinorrhea and rhinorrhea of various etiologies. According to ATX-classifier Nazivin assigned code R01AA05. 

Indications Nazivin

Nazivin can be prescribed for the treatment of rhinorrhea of various origins:

  • discharge from the nose, accompanying ARVI or ARI;
  • vasomotor runny nose;
  • an allergic rhinitis;
  • edema of the nasal cavity, sinusitis or sinusitis.

 In addition, Nazivin can be used to prepare for diagnostic procedures or operations in the nasal cavity.

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Release form

Intranasal drops of Nazivin are produced in glass bottles with a dispensing pipette, 10 ml of 0.025% and 0.05% of the drug, or 5 ml of 0.01% of the preparation. Drops have the appearance of a clear, sometimes slightly yellowish solution. Each flacon is packed in a separate cardboard box.

 A more convenient version of the drug Nazivin Sensitiv is also available in the form of a dosage spray containing 0.250 mg of oxymetazoline.

 In 10 g of drops contains:

  • oxymetazoline g / 0.1 mg, 0.25 mg or 0.5 mg;
  • additional components (benzalkonium chloride, sodium dihydrogen phosphate, sodium hydroxide, etc.).

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Pharmacodynamics

Spray Nazivin has an external vasoconstrictor effect. The active ingredient oxymetazoline is a synthetic adrenomimetic that activates adrenoreceptors located in the smooth musculature of the nasal vasculature.

Nazivin stops the rhinorrhea of any origin. The active substance oxymetazoline rapidly narrows the surface vessels, reduces the signs of swelling of the mucous tissues, facilitates breathing through the nose and restores the sense of smell.

Pharmacokinetics

Oxymetazoline begins to act immediately after applying the drug to the mucous membranes. The duration of the vasoconstrictive effect is up to 10 - 12 hours.

Systemic absorption of the active component is negligible. Excretion is carried out by means of kidneys (more than 2%) and intestines (more than 1%). The half-life is about 35 hours.

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Dosing and administration

Nasivin drops are used according to the following schemes:

  • adults and children from six years drip 1-2 drops of 0.05% Nasivin up to 3 times a day;
  • children 1-6 years drip 1-2 drops of 0.025% Nazivin up to 3 times a day;
  • Children up to 12 months of age drip 1 drop 0.01% of the drug up to 3 times a day.

Spray Nazivin Sensitiv provides for intranasal administration, which is carried out as follows:

  • children from 1 to 6 years use one injection of the drug 11.25 mkg / dose up to 3 times a day;
  • children older than 6 years use one injection of the drug 22.5 mcg / dose up to 3 times a day.

The frequency of application of the drug is 1 time in 8-12 hours. The duration of the treatment course is 4-7 days.

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Use Nazivin during pregnancy

Use of Nazivin during bearing is not recommended. Sometimes the drug can be prescribed only after a thorough assessment of the likely risks for the course of pregnancy and fetal development. In this case, the recommended doses of the drug should be closely followed.

During the lactation period, you can not use oxymetazoline.

Contraindications

  • Hyperactive sensitivity to oxymetazoline, a tendency to allergic reactions to other components of Nazivin.
  • Pathologies associated with metabolic disorders (thyroid disease, diabetes mellitus).
  • Increased intraocular pressure.
  • Atrophy of mucous membranes of the upper respiratory tract.
  • Simultaneous treatment with MAO inhibitor drugs, or other means that increase blood pressure.
  • Myocardial ischemia, hypertension, cardiac insufficiency.
  • Pronounced atherosclerotic vascular changes.
  • Heart rhythm disturbances.
  • Pheochromocytoma.
  • Hyperplasia of the prostate.

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Side effects Nazivin

With prolonged use of Nazivin, the following adverse events may develop:

  • soreness, itching and burning in the nasal cavity;
  • overdrying the nasal mucosa;
  • stuffiness in the nose, medicated rhinitis;
  • tachycardia, increased blood pressure, heart pain;
  • allergic manifestations (rash, hives, angioedema);
  • allergic conjunctivitis;
  • nausea, not associated with eating;
  • atrophic changes in the mucosa, frequent bleeding from the nose;
  • poor sleep, irritability;
  • feeling tired, pain in the head.

To avoid side effects, it is not recommended to use the drug oxymetazoline for a long time, and also to exceed the recommended dose. After the end of treatment, the mucosal structure is restored in most cases.

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Overdose

When using Nazivin for more than one week in a row, and if the medicine is accidentally swallowed, there may be signs of overdose:

  • dilated pupils;
  • dyspeptic disorders;
  • deterioration of the blood supply of the limbs;
  • spasms of peripheral vessels;
  • heart rhythm disorders;
  • insufficiency of cardiac activity;
  • collapse;
  • increased sweating;
  • pulmonary edema, respiratory function disorders;
  • blanching of the skin;
  • convulsions, nervous disorders.

Often, an overdose is accompanied by a violation of the central nervous system, which is manifested by fatigue, drowsiness, a drop in blood pressure, a coma.

When swallowing the drug is recommended to wash the stomach, take sorbent drugs. In severe cases, symptomatic treatment is performed.

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Interactions with other drugs

In complex treatment with other means that can narrow the blood vessels, there may be an increase in side effects.

Oxymetazoline blocks the absorption of other nasal drops and lengthens the period of their action, and also increases the effect on the central nervous system of MAO inhibitor drugs.

It is not recommended to use Nazivin for a long time, since this can provoke the development of atrophic changes in the mucous epithelium. For the same reasons, several local vasoconstrictors should not be used simultaneously.

For the treatment of chronic forms of rhinitis, Nazivin is administered in combination with other medications, depending on the cause of the common cold.

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Storage conditions

It is desirable to store Nazivin in dark places, away from children's access places. The optimum temperature regime for the preservation of the drug is from + 20 ° C to + 25 ° C.

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Shelf life

Shelf life of Nazivin drops and nasal spray Nazivin Sensitiv - up to 3 years.

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Attention!

To simplify the perception of information, this instruction for use of the drug "Nazivin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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