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The clearance of endogenous creatinine (Reberga-Tareev test)
Last reviewed: 18.10.2021
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The test of Reberg-Tareev allows to judge the glomerular filtration and tubular reabsorption in the kidneys. The test is based on the fact that creatinine is filtered only by the glomerulus, is not practically absorbed and secreted by the tubules in a small amount. The order of the sample is as follows: the patient wets in the morning, drinks 200 ml of water and then, on an empty stomach, in a state of complete rest, collects urine for a certain short time (2 hours). In the middle of this period of time, blood is taken from the vein. Determine the concentration of creatinine in the blood and urine collected in 2 hours. Calculate the coefficient of clearance (K Pts ) or the clearance of endogenous creatinine:
To Pts = (M / Pl.) XD (ml / min),
Where M is the concentration of creatinine in urine; Pl. - concentration of creatinine in plasma; D - minute diuresis in ml / min [equal to the amount of urine released in 2 hours (ml), divided by 120 min). By Pts expresses GFR. To determine GFR, urine collected per day can be examined.
Normally, GFR is 120 + 25 ml / min in men and 95 + 20 ml / min in women. GFR values are lowest in the morning, rise to maximum values during the day, and then decrease again in the evening. In healthy people, the decline in GFR occurs under the influence of heavy physical exertion and negative emotions; increases after drinking fluids and taking high-calorie food.