^

Health

A
A
A

Antibodies to tissue transglutaminase in the blood

 
, medical expert
Last reviewed: 18.10.2021
 
Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

The separation point is the antibody to tissue transglutaminase in serum above 10 IU / ml for IgA, and above 10 IU / ml for IgG.

Tissue transglutaminase belongs to a family of calcium-dependent acyltransferases that catalyze the formation of cross-links between proteins. It has now been established that tissue transglutaminase is the main, if not the only endomysial antigen in patients with celiac disease.

Determination of antibodies to tissue transglutaminase in blood serum is a highly specific method for diagnosing gluten enteropathy. For the detection of antibodies, the method of indirect immunofluorescence and ELISA is used. Antibodies to tissue transglutaminase can be detected in more than 95% of patients with celiac disease and their serum concentration correlates with the presence or absence of gluten in food. Antibodies of IgA class possess 95-100% sensitivity and 90-97% specificity.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]

Translation Disclaimer: For the convenience of users of the iLive portal this article has been translated into the current language, but has not yet been verified by a native speaker who has the necessary qualifications for this. In this regard, we warn you that the translation of this article may be incorrect, may contain lexical, syntactic and grammatical errors.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.